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He was anti-cyclic citrullinated peptide antibody negative, which makes the presence of comorbid chronic rheumatoid arthritis (RA) unlikely. The aetiology of the pachymeningitis was unknown, which led to the diagnosis of idiopathic hypertrophic cranial pachymeningitis. Steroid pulse therapy successfully diminished the patient\u2019s pachymeningitis and lowered both RF and MMP-3. High values of RF suggest the possible involvement of an autoimmune mechanism, and the MMP value may be an important indicator of the aetiology of pachymeningitis with granulomatous vasculitis.<\/jats:p>","DOI":"10.1136\/bcr.06.2009.2016","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T12:04:24Z","timestamp":1267099464000},"page":"bcr0620092016","source":"Crossref","is-referenced-by-count":2,"title":["A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase"],"prefix":"10.1136","volume":"2010","author":[{"given":"Kiyotaka","family":"Nakamagoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai","family":"Hosaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzuru","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tamaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.4.300"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.2","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.43.7.1329","article-title":"Cranial pachymeningitis of unknown origin: a study of seven cases","volume":"43","author":"Masson","year":"1993","journal-title":"Neurology"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1212\/01.WNL.0000113748.53023.B7","article-title":"Idiopathic hypertrophic pachymeningitis","volume":"62","author":"Kupersmith","year":"2004","journal-title":"Neurology"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00282.x"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.5","first-page":"1247","article-title":"Evaluation of pachymeningitis by contrast-enhanced MR imaging in a patient with rheumatoid disease","volume":"11","author":"Yuh","year":"1990","journal-title":"Am J Neuroradiol"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0615-9"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.7","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-003-0815-1"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.8","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1212\/WNL.50.4.1190","article-title":"Pachymeningitis with a perinuclear antineutrophil cytoplasmic antibody: response to pulse steroid","volume":"50","author":"Takahashi","year":"1998","journal-title":"Neurology"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.9","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/art.1780370807","article-title":"Dynamic magnetic resonance imaging for the evaluation of synovitis in patients with rheumatoid arthritis","volume":"37","author":"Tamai","year":"1994","journal-title":"Arthritis Rheum"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.10","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.4.407"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000090689.69973.B1"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.12","doi-asserted-by":"publisher","DOI":"10.1161\/hc3301.095286"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.13","first-page":"689","article-title":"The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis","volume":"17","author":"Van Jaarsveld","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.14","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3"},{"key":"2025042508281058000_2010.feb25_1.bcr0620092016.15","doi-asserted-by":"crossref","unstructured":"Woessner JF JR . 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