{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T11:10:01Z","timestamp":1756293001690,"version":"3.44.0"},"reference-count":6,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>A 47-year-old male presented with chest discomfort while sleeping. The patient was suspected of having vasospastic angina (VSA) and underwent hyperventilation and cold-pressor stress echocardiography. No chest pain, ECG changes or decreased wall motion was found. However, automated function imaging (AFI) showed decreased peak systolic strain at the apex and postsystolic shortening at both the apex and inferior wall, which was not found before the test. The provocation test revealed 99% stenosis in the right coronary artery #2 at a dose of 50 \u03bcg acetylcholine and 90% stenosis in the left coronary artery #8 at a dose of 100 \u03bcg. The patient was thus diagnosed as having VSA. The present case demonstrates the usefulness of AFI combined with hyperventilation and cold-pressor stress echocardiography as a screening examination for VSA.<\/jats:p>","DOI":"10.1136\/bcr.06.2010.3060","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T12:03:51Z","timestamp":1291032231000},"page":"bcr0620103060","source":"Crossref","is-referenced-by-count":0,"title":["Hyperventilation and cold-pressor stress echocardiography combined with automated functional imaging non-invasively detected vasospastic angina"],"prefix":"10.1136","volume":"2010","author":[{"given":"Kengo","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro J","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Mizukoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seisyou","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Takai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Izumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shimozato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ohtaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachihiko","family":"Nobuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Miyake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.1","first-page":"257","article-title":"Induction of coronary artery spasm by combined cold pressor and hyperventilation test in patients with variant angina","volume":"24","author":"Shimizu","year":"1994","journal-title":"J Cardiol"},{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90406-X"},{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.3","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2001.112110"},{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.35.6.896","article-title":"Regional myocardial function during acute coronary artery occlusion and its modification by pharmacologic agents in the dog","volume":"35","author":"Theroux","year":"1974","journal-title":"Circ Res"},{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00000542-198110000-00004","article-title":"Regional ischemic ventricular dysfunction in myocardium supplied by a narrowed coronary artery with increasing halothane concentration in the dog","volume":"55","author":"Lowenstein","year":"1981","journal-title":"Anesthesiology"},{"key":"2025082703372813000_2010.nov26_1.bcr0620103060.6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.4.215"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.06.2010.3060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:37:37Z","timestamp":1756291057000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.06.2010.3060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":6,"alternative-id":["10.1136\/bcr.06.2010.3060"],"URL":"https:\/\/doi.org\/10.1136\/bcr.06.2010.3060","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2010]]}}}