{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:16:00Z","timestamp":1764173760434,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, is a type of drug hypersensitivity syndrome, is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute hepatic failure. In this article, the authors report a case of DRESS syndrome with severe exfoliative dermatitis with acute hepatitis associated with intake of leflunomide. Rapid diagnosis with withdrawal of offending agent is crucial for survival of these cases.<\/jats:p>","DOI":"10.1136\/bcr.06.2011.4330","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T11:17:59Z","timestamp":1315221479000},"page":"bcr0620114330","source":"Crossref","is-referenced-by-count":12,"title":["An unusual case of DRESS syndrome due to leflunomide"],"prefix":"10.1136","volume":"2011","author":[{"given":"Arvind Kumar","family":"Vaish","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil Kumar","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokesh Kumar","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirdesh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.06.002"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.2","doi-asserted-by":"publisher","DOI":"10.1159\/000069956"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.3","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091266"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.55.1","article-title":"Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses.","volume":"55","author":"Shiohara","year":"2006","journal-title":"Allergol Int"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.5","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.198"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.6","first-page":"154","article-title":"Leflunomide induced drug rash and hepatotoxicity","volume":"49","author":"Uppal","year":"2004","journal-title":"Indian J Dermatol"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1000-1948(10)60020-2"},{"key":"2025082703293276000_2011.sep04_1.bcr0620114330.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.06.2011.4330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:29:42Z","timestamp":1756290582000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.06.2011.4330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,5]]},"references-count":8,"alternative-id":["10.1136\/bcr.06.2011.4330"],"URL":"https:\/\/doi.org\/10.1136\/bcr.06.2011.4330","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,9,5]]}}}