{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:58:51Z","timestamp":1758815931254,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Clarkson\u2019s syndrome, also called idiopathic systemic capillary leak syndrome is a rare condition characterised by vascular hyper permeability resulting in extreme intravascular volume depletion. The syndrome is unique and almost paradoxical in its presentation, with findings initially suggesting overwhelming heart failure, but in reality the extra vascular fluid represents overt capillary leak, with ultimate intravascular volume depletion, a low output state and hypovolemic shock. Previously described characteristics have classically included severe oedema and anasarca with rapid, profound shock, typically accompanied by haemoconcentration. The authors describe a patient, initially seeming benign in presentation, who rapidly progressed with confusing findings of fluid overload by examination and imaging, ultimately manifesting these findings by severe capillary leak rather than hydrostatic oedema, with ultimate hypovolaemic shock, multisystem organ failure and death. Our aim is that by describing clinical, haemodynamic and pathologic descriptors of the disease, the authors can aid in increasing physician awareness of this unusual syndrome.<\/jats:p>","DOI":"10.1136\/bcr.06.2011.4405","type":"journal-article","created":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T14:59:14Z","timestamp":1314889154000},"page":"bcr0620114405","source":"Crossref","is-referenced-by-count":2,"title":["An unusual case of swelling- Clarkson\u2019s syndrome"],"prefix":"10.1136","volume":"2011","author":[{"given":"Asif","family":"Ansari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KC","family":"Birendra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew","family":"Marvin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Kubat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,9,1]]},"reference":[{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(60)90018-8"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-153-2-201007200-00005"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.3","first-page":"515","article-title":"Systemic capillary leak syndrome.","volume":"75","author":"Teelucksingh","year":"1990","journal-title":"Q J Med"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1691"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.4.1301"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.4049\/jimmunol.137.5.1735","article-title":"Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.","volume":"137","author":"Rosenstein","year":"1986","journal-title":"J Immunol"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.492"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00272-6"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.9","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2249.1993.tb08195.x","article-title":"The paraproteins in systemic capillary leak syndrome.","volume":"93","author":"Zhang","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.10","doi-asserted-by":"publisher","DOI":"10.4065\/73.4.346"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.7326\/0003-4819-130-11-199906010-00015","article-title":"Treatment of the systemic capillary leak syndrome with terbutaline and theophylline. A case series.","volume":"130","author":"Tahirkheli","year":"1999","journal-title":"Ann Intern Med"},{"key":"2025082801455784000_2011.aug31_1.bcr0620114405.12","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-1891(03)00014-4"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.06.2011.4405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:46:02Z","timestamp":1756370762000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.06.2011.4405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":12,"alternative-id":["10.1136\/bcr.06.2011.4405"],"URL":"https:\/\/doi.org\/10.1136\/bcr.06.2011.4405","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}