{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:07:28Z","timestamp":1745640448975,"version":"3.40.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:sec><jats:title>Introduction:<\/jats:title><jats:p>Spontaneous haemoperitoneum due to rupture of hepatocellular carcinoma (HCC) is a surgical emergency and may have catastrophic outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical picture:<\/jats:title><jats:p>A 62-year-old male presented with nausea, dizziness and low back pain. There was no history of malignancy. Physical examination revealed a surgical abdominal emergency, but there was no physical finding that pointed towards a specific diagnosis. Laboratory studies revealed decreased haematocrit (27.6%) and increased INR (2.8) levels. A computed tomography scan showed a tumoral lesion within the fourth segment of the liver and fluid collection (haemoperitoneum) with normal vascular and intra-abdominal structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment:<\/jats:title><jats:p>Exploratory laparotomy was performed; the appearance of the liver was cirrhotic and nodular. Actively bleeding tumoral lesion was confirmed in fourth segment of the liver, \u201cpacking\u201d applied with sponges to stop bleeding. On the post-operative day 22, the patient was discharged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Spontaneous rupture of HCC is rare and should be considered in the differential diagnosis of non-traumatic spontaneous haemoperitoneum.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bcr.07.2008.0580","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T21:33:45Z","timestamp":1235684025000},"page":"bcr0720080580","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous rupture of hepatocellular carcinoma presented as low back pain to an emergency department: a case report: Figure 1"],"prefix":"10.1136","volume":"2009","author":[{"given":"Ozge Ozberk","family":"Onur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Guneysel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Saritemur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu","family":"Denizbasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.1","first-page":"67","article-title":"Spontaneous rupture of hepatocellular carcinoma: a review of 172 Japanese cases","volume":"86","author":"Miyamoto","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(02)00466-3"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.3","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199510000-00015"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.4","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1200\/JCO.2001.19.17.3725","article-title":"Management of spontaneous rupture of hepatocellular carcinoma: single center experience","volume":"19","author":"Liu","year":"2001","journal-title":"J Clin Oncol"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.5","first-page":"49","article-title":"Ruptured hepatocellular carcinoma following chemoembolization: a western experience","volume":"6","author":"Battula","year":"2007","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.6","first-page":"159","article-title":"Computed tomography and angiographic \u0131nterventional features of ruptured hepatocellular carcinoma: pictorial essay","volume":"57","author":"Kim","year":"2006","journal-title":"Can Assoc Radiol J"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.02.052"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03750.x"},{"key":"2025042507262336000_2009.feb24_1.bcr0720080580.9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.2214\/ajr.158.6.1317090","article-title":"Rupture of hepatocellular carcinoma: predictive value of CT findings","volume":"158","author":"Kanematsu","year":"1992","journal-title":"AJR Am J Roentgenol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.07.2008.0580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:26:29Z","timestamp":1745591189000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.07.2008.0580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":9,"alternative-id":["10.1136\/bcr.07.2008.0580"],"URL":"https:\/\/doi.org\/10.1136\/bcr.07.2008.0580","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}