{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:53:51Z","timestamp":1773298431805,"version":"3.50.1"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Androgen secreting tumours are the least commonly encountered androgen excess disorders, having a prevalence of 0.2%. Androblastomas of the ovary comprise less than 0.5% of all ovarian tumours. Pure Leydig cell tumours are very rare and almost always show secretion of male sex hormones.<\/jats:p><jats:p>A 41-year-old multipara Filipino woman presented with a 2-year history of amenorrhoea and virilisation characterised by hirsutism, androgenic alopecia, masculine habitus and clitoromegaly. Diagnostic evaluation showed markedly elevated serum testosterone and normal dehydroepiandrosterone sulfate. Normal ovaries were seen on initial transvaginal ultrasound. A low dose dexamethasone suppression test suggested an ovarian source. A left adrenal nodule was seen on CT scan. Doppler transvaginal ultrasound revealed a solid lobulated structure in the right ovary. The patient underwent surgery and histopathology showed a Leydig cell tumour, hilar type. Serum testosterone levels normalised 3 days after surgery.<\/jats:p><jats:p>Specific clinical and biochemical investigation of androgen secreting neoplasms is very important for correct diagnosis of these rare tumours.<\/jats:p>","DOI":"10.1136\/bcr.07.2010.3139","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T10:48:20Z","timestamp":1292410100000},"page":"bcr0720103139","source":"Crossref","is-referenced-by-count":4,"title":["Virilising ovarian tumour in a woman with an adrenal nodule"],"prefix":"10.1136","volume":"2010","author":[{"given":"Maria Luisa Cecilia","family":"Rivera-Arkoncel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debby","family":"Pacquing-Songco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances Lina","family":"Lantion-Ang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,12,15]]},"reference":[{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031122"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1457"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<187::AID-CNCR2820480130>3.0.CO;2-1"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.4","first-page":"121","article-title":"The molecular biology of Sertoli-leydig cell tumors of the ovary","volume":"7","author":"Wenham","year":"2002","journal-title":"CME Journal of Gynecol Oncol"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.5","first-page":"121","article-title":"AACE Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Hyperandrogenic Disorders","volume":"7","author":"Hyperandrogenic Disorders Task Force","year":"2001","journal-title":"Endocr Pract"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.6","doi-asserted-by":"crossref","unstructured":"Pugeat M Raverot G Plotton I . Androgen secreting adrenal and ovarian \\nNeoplasms. In: Azziz R Nestler JE Dewailly D , eds. Contemporary Endocrinology: Androgen Excess Disorders in Women, PCOS and other Disorders. Second edition. Totowa, New Jersey: Humana Press Inc 2006:.75\u201382","DOI":"10.1007\/978-1-59745-179-6_6"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.7","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500369005"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.8","doi-asserted-by":"crossref","unstructured":"Dewailly D Azziz R . The nonclassic adrenal hyperplasias. In: Azziz R Nestler JE Dewailly D , eds. Contemporary Endocrinology: Androgen Excess Disorders in Women, Polycystic Ovary Syndrome and Other Disorders. Second edition. Totowa, New Jersey: Humana Press Inc 2006: 91\u2013102.","DOI":"10.1007\/978-1-59745-179-6_8"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.9","doi-asserted-by":"crossref","unstructured":"Neraud B Dewailly D . Drug-induced hyperandrogenism. In: Azziz R Nestler JE Dewailly D , eds. Contemporary Endocrinology: Androgen Excess Disorders in Women, Polycystic Ovarian Syndrome and Other Disorders. Second edition. Totowa, New Jersey: Humana Press Inc 2006:121\u2013124.","DOI":"10.1007\/978-1-59745-179-6_10"},{"issue":"2","key":"2025042509023491000_2010.dec13_1.bcr0720103139.10","first-page":"1","article-title":"Diagnosing Hyperandrogenism in Women","volume":"6","author":"Kraw","year":"2006","journal-title":"Endocrinol Rnds"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp033496"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020922"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.13","first-page":"33","article-title":"Hilar Leydig cell tumor presenting as hirsutism in a 51-year-old woman","volume":"43","author":"Grover","year":"2007","journal-title":"Hospital Physician"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.14","first-page":"191","article-title":"Masculinizing ovarian tumor","volume":"20","author":"Alumisin","year":"1996","journal-title":"Phil J Obstet Gynecol"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.15","first-page":"111","article-title":"Lipoid cell tumor of the ovary: a case report","volume":"26","author":"Constantino","year":"2002","journal-title":"Phil J Obstet Gynecol"},{"key":"2025042509023491000_2010.dec13_1.bcr0720103139.16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.7.3074"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.07.2010.3139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T16:02:48Z","timestamp":1745596968000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.07.2010.3139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"alternative-id":["10.1136\/bcr.07.2010.3139"],"URL":"https:\/\/doi.org\/10.1136\/bcr.07.2010.3139","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}