{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:16:03Z","timestamp":1762917363227,"version":"3.40.4"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 61-year-old woman was admitted with history of vomiting, diarrhoea and severe hyponatraemia (Na<jats:sup>+<\/jats:sup>109). The cause of the hyponatraemia was due to intravascular volume depletion resulting in a non-osmotic release of antidiuretic hormone (ADH) with the added effects of a thiazide diuretic. She was also on fluoxetine which may induce inappropriate secretion of ADH. Despite cautious fluid replacement, the patient\u2019s serum sodium increased by 12 mmol\/l over the first 18 h (and by 10 mmol\/l over 12 h). This trajectory, coupled with the rapid decrease in urine osmolality, suggested that this patient was at risk of significant brain injury due to rapid correction of serum sodium. The use of desmopressin slowed the rise in serum sodium allowing brain adaptive mechanisms time to protect against osmotic demyelination.<\/jats:p>","DOI":"10.1136\/bcr.07.2011.4512","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T15:54:39Z","timestamp":1320854079000},"page":"bcr0720114512","source":"Crossref","is-referenced-by-count":4,"title":["Preventing overcorrection of hyponatraemia with desmopressin: Figure 1"],"prefix":"10.1136","volume":"2011","author":[{"given":"Sophie Claire","family":"Tomlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Riley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,11,9]]},"reference":[{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.21"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.2","unstructured":"Sterns RH . Osmotic demyelination syndrome and overly rapid correction of hyponatraemia. UpToDate 18:2010."},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01210211"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-5-656"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.5","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ki.1990.78","article-title":"Treating hyponatremia: damned if we do and damned if we don\u2019t.","volume":"37","author":"Berl","year":"1990","journal-title":"Kidney Int"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00005792-199311000-00001","article-title":"Pontine and extrapontine myelinolysis: a neurologic disorder following rapid correction of hyponatremia.","volume":"72","author":"Karp","year":"1993","journal-title":"Medicine (Baltimore)"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.7","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1681\/ASN.V481522","article-title":"Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective.","volume":"4","author":"Sterns","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00910207"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.23"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.10","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1053\/ajkd.2000.9013","article-title":"Overcorrection of hyponatremia: where do we go wrong?","volume":"36","author":"Pham","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.254"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.12","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03190807"},{"key":"2025042708153117000_2011.nov08_1.bcr0720114512.13","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.251"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.07.2011.4512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:15:41Z","timestamp":1745766941000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.07.2011.4512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,9]]},"references-count":13,"alternative-id":["10.1136\/bcr.07.2011.4512"],"URL":"https:\/\/doi.org\/10.1136\/bcr.07.2011.4512","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,11,9]]}}}