{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:40:07Z","timestamp":1745768407544,"version":"3.40.4"},"reference-count":1,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Acute psychiatric illness with agitation presents the clinician with a dangerous, potentially life-threatening situation often requiring complex management. Alteration in patients\u2019 insight and judgment may result in medication non-compliance, potentially further complicating therapy directed at the primary psychiatric illness as well as any co-existing conditions. Sedation is often necessary to control dangerous behaviour during the period of antipsychotic and mood-stabilising drug titration. Dexmedetomidine is a centrally acting selective \u03b12-adrenergic agonist with anaesthetic and sedative properties widely used in intensive care units for sedation in critically ill patients. The authors report the case of a patient managed successfully with dexmedetomidine sedation while being treated for acute mania and perineal abscess.<\/jats:p>","DOI":"10.1136\/bcr.07.2011.4543","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T18:54:51Z","timestamp":1318013691000},"page":"bcr0720114543","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of acute mania and perineal abscess using dexmedetomidine sedation as adjunctive therapy"],"prefix":"10.1136","volume":"2011","author":[{"given":"Adam L.","family":"Ackerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristin","family":"Mount","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"2025042708085367000_2011.oct03_1.bcr0720114543.1","doi-asserted-by":"publisher","DOI":"10.1097\/YCT.0b013e3181b07c26"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.07.2011.4543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:09:05Z","timestamp":1745766545000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.07.2011.4543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,7]]},"references-count":1,"alternative-id":["10.1136\/bcr.07.2011.4543"],"URL":"https:\/\/doi.org\/10.1136\/bcr.07.2011.4543","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,10,7]]}}}