{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:50:06Z","timestamp":1772070606838,"version":"3.50.1"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"abstract":"<jats:p>Holmes\u2019 tremor refers to an unusual combination of rest, postural and kinetic tremor of extremities. Common causes of Holmes\u2019 tremor include stroke, trauma, vascular malformations and multiple sclerosis, with lesions involving the thalamus, brain stem or cerebellum. Although some drugs (eg, levodopa and dopaminergic drugs, clonazepam and propranolol) have been occasionally reported to give some benefit, medical treatment of Holmes\u2019 tremor is unsatisfactory, and many patients require thalamic surgery to achieve satisfactory control. We report a patient in whom post-ischaemic Holmes\u2019 tremor dramatically responded to levetiracetam treatment.<\/jats:p>","DOI":"10.1136\/bcr.08.2008.0643","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T13:33:18Z","timestamp":1232717598000},"page":"bcr0820080643","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Dramatic response to levetiracetam in post-ischaemic Holmes\u2019 tremor"],"prefix":"10.1136","volume":"2009","author":[{"given":"P","family":"Striano","sequence":"first","affiliation":[{"name":"Federico II University, Via Pansini 5, Naples, 80131, Italy"},{"name":"G. Gaslini Insit, Largo Gaslini 5, Genova, 16124, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Elefante","sequence":"additional","affiliation":[{"name":"Federico II University, Via Pansini 5, Naples, 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Coppola","sequence":"additional","affiliation":[{"name":"Federico II University, Via Pansini 5, Naples, 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tortora","sequence":"additional","affiliation":[{"name":"Federico II University, Via Pansini 5, Naples, 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Zara","sequence":"additional","affiliation":[{"name":"G. Gaslini Insit, Largo Gaslini 5, Genova, 16124, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Minetti","sequence":"additional","affiliation":[{"name":"G. Gaslini Insit, Largo Gaslini 5, Genova, 16124, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"2025082623463285000_2009.aug06_1.bcr0820080643.1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130104"},{"key":"2025082623463285000_2009.aug06_1.bcr0820080643.2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.4.453"},{"key":"2025082623463285000_2009.aug06_1.bcr0820080643.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308208101"},{"key":"2025082623463285000_2009.aug06_1.bcr0820080643.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0112-4"},{"key":"2025082623463285000_2009.aug06_1.bcr0820080643.5","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1212\/01.WNL.0000154596.21335.2E","article-title":"The effect of levetiracetam on essential tremor","volume":"64","author":"Bushara","year":"2005","journal-title":"Neurology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.08.2008.0643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T06:46:45Z","timestamp":1756277205000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.08.2008.0643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":5,"alternative-id":["10.1136\/bcr.08.2008.0643"],"URL":"https:\/\/doi.org\/10.1136\/bcr.08.2008.0643","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}