{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:40:01Z","timestamp":1756320001836,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"abstract":"<jats:p>Several neurological disorders have been associated with coeliac disease, including epilepsy, ataxia and neuropathy. Here we report a rare case of white matter disease in a 55-year-old man with coeliac disease. He presented with anxiety, headache and left upper limb jerking. He subsequently developed epilepsy and brain MRI revealed diffuse white matter abnormality. He died 6 months after presentation due to status epilepticus and sepsis. Brain biopsy demonstrated vacuolar leucoencephalopathy with no evidence of vCJD. An extensive clinical screen excluded infectious, inflammatory and para-neoplastic causes for this condition. Coeliac disease may be causally associated with vacuolar leucoencephalopathy in this case.<\/jats:p>","DOI":"10.1136\/bcr.08.2008.0650","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T13:33:18Z","timestamp":1232717598000},"page":"bcr0820080650","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease"],"prefix":"10.1136","volume":"2009","author":[{"given":"A M","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Neurology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Wan-Ahmed","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Hardiman","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Institute for Neurology and Neurosurgery, Beaumont Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Farrell","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, National Institute for Neurology and Neurosurgery, Beaumont Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cork University Hospital, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,8]]},"reference":[{"key":"2025082711270635000_2009.aug06_1.bcr0820080650.1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.3.385"},{"key":"2025082711270635000_2009.aug06_1.bcr0820080650.2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/89.4.683"},{"key":"2025082711270635000_2009.aug06_1.bcr0820080650.3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1212\/WNL.50.3.820","article-title":"Chronic progressive leukoencephalopathy in adult celiac disease","volume":"50","author":"Beyenburg","year":"1998","journal-title":"Neurology"},{"key":"2025082711270635000_2009.aug06_1.bcr0820080650.4","first-page":"1560","article-title":"Diagnosing variant Creutzfeldt-Jakob disease with the pulvinar sign:MR imaging findings in 86 neuropathologically confirmed cases","volume":"24","author":"Collie","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"2025082711270635000_2009.aug06_1.bcr0820080650.5","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901401108"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.08.2008.0650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:27:12Z","timestamp":1756319232000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.08.2008.0650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,8]]},"references-count":5,"alternative-id":["10.1136\/bcr.08.2008.0650"],"URL":"https:\/\/doi.org\/10.1136\/bcr.08.2008.0650","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,8,8]]}}}