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Treatment with Cabergolin resulted in a normalisation of prolactin levels and a decrease in tumour size. During follow-up, the patient presented a permanent state of passivity and disinterest in imaginative experiences, without any obvious specific diagnoses, according to psychiatric examination. Further investigations showed major depression, schizotypical personality and patterns of psychotic functioning. Initial treatment with selective serotonin re-uptake inhibitors was not effective and he was switched to an atypical antipsychotic drug that was not tolerated and rapidly stopped by the patient.<\/jats:p>","DOI":"10.1136\/bcr.08.2008.0741","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T10:17:37Z","timestamp":1238062657000},"page":"bcr0820080741","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis and treatment difficulties of psychiatric symptoms in Klinefelter syndrome: a case report"],"prefix":"10.1136","volume":"2009","author":[{"given":"Ines","family":"Slim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousri 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