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In particular his hyperlipidaemia, hyperglycaemia, proinflammatory state, evidence of hepatic and renal insufficiency, arterial stiffness, and extensive and chronic cutaneous ulceration all improved dramatically over just 13 weeks, in association with complete control of his heroin, benzodiazepine, tobacco and cannabis use. The metabolic and vascular benefits were all highly statistically significant. The case is the first to document dramatic and rapid metabolic, immune and vascular improvements in association with clinical naltrexone therapy and are consistent with its likely effects in restoring addiction-related stem cell and immunological deficits.<\/jats:p>","DOI":"10.1136\/bcr.08.2008.0799","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T09:38:20Z","timestamp":1239701900000},"page":"bcr0820080799","source":"Crossref","is-referenced-by-count":2,"title":["Improved parameters of metabolic glycaemic and immune function and arterial stiffness with naltrexone implant therapy"],"prefix":"10.1136","volume":"2009","author":[{"given":"Albert Stuart","family":"Reece","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"2025042507452639000_2009.apr07_2.bcr0820080799.1","unstructured":"O\u2019Brien CP . 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