{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:29:15Z","timestamp":1761128955182,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A 75-year old-female was referred with chest pain. She was fully investigated and it was felt that her symptoms were non-cardiac. Four months later, she was seen in gastroenterology outpatients with bloody diarrhoea and abdominal pain. Colonoscopy demonstrated inflammation up to the splenic flexure and histology confirmed inflammatory colitis. Later, she developed dyspepsia and weight loss. An oesophagogastroduodenoscopy (OGD) showed <jats:italic>Helicobacter pylori<\/jats:italic> negative erosive gastritis with a benign duodenal ulcer. Whole body CT scan was normal. Ten months later, she was admitted with dyspnoea due to severe heart failure. The admission ECG had significantly changed, now showing low voltage complexes and repeat echocardiography showed restrictive cardiomyopathy. Specific congo red staining on the biopsy specimens from the previous OGD and colonoscopy confirmed amyloid deposits. Further investigations detected an underlying light chain myeloma causing systemic (AL) amyloidosis. Unfortunately, her condition deteriorated rapidly and she died shortly afterwards.<\/jats:p>","DOI":"10.1136\/bcr.08.2011.4596","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T14:54:51Z","timestamp":1317999291000},"page":"bcr0820114596","source":"Crossref","is-referenced-by-count":5,"title":["Primary systemic amyloidosis presenting as idiopathic inflammatory colitis"],"prefix":"10.1136","volume":"2011","author":[{"given":"Nadeem","family":"Rahman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Toqeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Hawley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Weston-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark W","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan Willem","family":"Rademaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"McWilliams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,10,7]]},"reference":[{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02629550"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.2","first-page":"40","article-title":"Amyloidosis presenting as lower gastrointestinal hemorrhage.","volume":"107","author":"Spier","year":"2008","journal-title":"WMJ"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.3","doi-asserted-by":"publisher","DOI":"10.1080\/00365520410008105"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.4","first-page":"74","article-title":"Diarrhea in gastrointestinal amyloidosis: a case report and review of the literature","volume":"27","author":"Ho","year":"2003","journal-title":"Pract Gastroenterol"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01887327"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.6","first-page":"207","article-title":"Primary amyloid tumors of the jejunum producing intestinal obstruction.","volume":"39","author":"Hamaya","year":"1989","journal-title":"Acta Pathol Jpn"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235077"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.8","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02740806"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01669.x"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.02.038"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.supp3.142"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.12","doi-asserted-by":"publisher","DOI":"10.1007\/s100670170048"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.13","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0025-6196(12)60634-X","article-title":"Symptomatic gastric amyloidosis in patients with primary gastric amyloidosis","volume":"68","author":"Menke","year":"1993","journal-title":"Mayo clinic Proc"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.14","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.64.755.696"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.15","doi-asserted-by":"crossref","first-page":"943","DOI":"10.7326\/0003-4819-55-6-943","article-title":"Amyloidosis.","volume":"55","author":"Briggs","year":"1961","journal-title":"Ann Intern Med"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2214\/ajr.110.2.406","article-title":"Roentgenologic appearance of systemic amyloidosis involving gastrointestinal tract.","volume":"110","author":"Legge","year":"1970","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.17","doi-asserted-by":"crossref","unstructured":"Basavaraju KP Mansour D Barnes S . A rare cause of dysphagia and gastroparesis. BMJ Case Reports 2009; doi:10.1136\/bcr.07.2008.0358.","DOI":"10.1136\/bcr.07.2008.0358"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01208-1"},{"key":"2025082802105925000_2011.oct03_1.bcr0820114596.19","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6403-x"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.08.2011.4596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:11:07Z","timestamp":1756372267000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.08.2011.4596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,7]]},"references-count":19,"alternative-id":["10.1136\/bcr.08.2011.4596"],"URL":"https:\/\/doi.org\/10.1136\/bcr.08.2011.4596","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,10,7]]}}}