{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:07:37Z","timestamp":1745640457271,"version":"3.40.4"},"reference-count":10,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>This report describes a case of acute lymphoblastic leukaemia in which isochromosome 9q (i(9q)) was the sole acquired cytogenetic abnormality. The Immunophenotype showed positivity for CD3, CD4, CD5, CD7, CD8, CD10, CD71, CD117 and TdT, consistent with T cell acute lymphoblastic leukaemia (ALL). The chromosomal analysis of bone marrow showed 46,XY,i(9)(q10) in all the metaphases analysed. The bone marrow morphology was ALL-L2 as per the French\u2013American\u2013British criteria. Isochromosomes are rare chromosomal abnormalities in childhood ALL and the effect of i(9q) is not well established. The patient\u2019s good response to therapy with normal cytogenetics within a month of induction, and disease-free survival after bone marrow transplant are indicative of a good prognosis in such cases.<\/jats:p>","DOI":"10.1136\/bcr.09.2008.0890","type":"journal-article","created":{"date-parts":[[2009,4,28]],"date-time":"2009-04-28T11:13:40Z","timestamp":1240917220000},"page":"bcr0920080890","source":"Crossref","is-referenced-by-count":2,"title":["Isochromosome 9q as a sole anomaly in an Omani boy with acute lymphoblastic leukaemia: Figure 1"],"prefix":"10.1136","volume":"2009","author":[{"given":"Udayakumar Muthappa","family":"Achandira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil V","family":"Pathare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salam Al","family":"Kindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Dennison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said Al","family":"Yahyaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,4,28]]},"reference":[{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000133022","article-title":"Report of the committee on chromosome changes in neoplasia","volume":"55","author":"Mitelman","year":"1990","journal-title":"Cytogenet Cell Genet"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.2","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1182\/blood.V79.9.2384.2384","article-title":"Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases","volume":"79","author":"Pui","year":"1992","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"2025042507485633000_2009.apr23_1.bcr0920080890.3","DOI":"10.1002\/(SICI)1098-2264(199609)17:1<21::AID-GCC4>3.0.CO;2-4"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.4","first-page":"195","article-title":"Isochromosome 9q in acute lymphoblastic leukemia: a new non-random finding","volume":"3","author":"Shippey","year":"1989","journal-title":"Leukemia"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/gcc.2870100402","article-title":"Isochromosomes in neoplasia","volume":"10","author":"Mertens","year":"1994","journal-title":"Genes Chromosomes Cancer"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.6","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1182\/blood.V91.11.3995","article-title":"Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia","volume":"91","author":"Faderl","year":"1998","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"2025042507485633000_2009.apr23_1.bcr0920080890.7","DOI":"10.1016\/j.leukres.2006.02.018"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199001113220202","article-title":"Deletions of interferon genes in acute lymphoblastic leukemia","volume":"322","author":"Diaz","year":"1990","journal-title":"N Engl J Med"},{"doi-asserted-by":"publisher","key":"2025042507485633000_2009.apr23_1.bcr0920080890.9","DOI":"10.1002\/gcc.2870080402"},{"key":"2025042507485633000_2009.apr23_1.bcr0920080890.10","first-page":"541","article-title":"Abnormalities of the short arm of chromosome 9 with partial loss of material in hematological disorders","volume":"1","author":"Pollak","year":"1987","journal-title":"Leukemia"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.09.2008.0890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:49:04Z","timestamp":1745592544000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.09.2008.0890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":10,"alternative-id":["10.1136\/bcr.09.2008.0890"],"URL":"https:\/\/doi.org\/10.1136\/bcr.09.2008.0890","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}