{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T09:50:44Z","timestamp":1756461044648,"version":"3.40.4"},"reference-count":9,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>A 41-year-old homosexual man presented with a 10-week history of headache without pressure features commencing 10 weeks after a new sexual contact. Three days after the headache onset he noticed intermittent, bilateral visual blurring, worse in the right eye. The visual disturbance persisted intermittently and led to his referral to a local ophthalmology department where he was found to have bilateral papilloedema. There were no other abnormal signs on full examination of other systems and no other abnormal ocular findings. Cerebral imaging studies were normal. A lumbar puncture revealed a raised opening pressure of 35 mm cerebrospinal fluid (CSF) with a white cell count of 58 cells\/mcl (mainly lymphocytes). Venereal disease research laboratory (VDRL),<jats:italic>Treponema pallidum<\/jats:italic>haemagglutination (TPHA) and Inno-LIA tests confirmed the presence of neurosyphilis. HIV testing was negative. He was treated with CSF pressure reduction via repeat lumbar puncture and acetozolamide and procaine penicillin intramuscularly. He recovered and remains symptom free at 1 year.<\/jats:p>","DOI":"10.1136\/bcr.09.2008.1008","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T19:41:52Z","timestamp":1237318912000},"page":"bcr0920081008","source":"Crossref","is-referenced-by-count":4,"title":["Syphilis presenting with headache and papilloedema"],"prefix":"10.1136","volume":"2009","author":[{"given":"Sarah","family":"Cooper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Razvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Browne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,3,17]]},"reference":[{"unstructured":"HIV and Sexually Transmitted Infections Department. Diagnoses of selected STIs by region, sex and age group, United Kingdom: 1995\u00e2\u0080\u00932004. London: Health Protection Agency, 2005: 1\u00e2\u0080\u009317.","key":"2025042507385214000_2009.mar08_1.bcr0920081008.1"},{"unstructured":"HIV and Sexually Transmitted Infections Department. Diagnoses and rates of selected STIs seen at GUM clinics: 2002\u00e2\u0080\u00932006. London: Health Protection Agency, 2007: 1\u00e2\u0080\u009334.","key":"2025042507385214000_2009.mar08_1.bcr0920081008.2"},{"key":"2025042507385214000_2009.mar08_1.bcr0920081008.3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00007611-197708000-00037","article-title":"Syphiltic meningitis with papilloedema","volume":"70","author":"Trenholme","year":"1977","journal-title":"South Med J"},{"unstructured":"Lesser R . Spirochetal diseases. In: Miller N R Newman N J , eds. Walsh and Hoyt\u00e2\u0080\u0099s Clinical Neuroophthalmology. Sixth edition. Lippincott, Williams and Wilkins, 2005: 3094\u00e2\u0080\u00935.","key":"2025042507385214000_2009.mar08_1.bcr0920081008.4"},{"unstructured":"Worster-Drought C . Neurosyphilis. London: John Bale and Sons, 1940.","key":"2025042507385214000_2009.mar08_1.bcr0920081008.5"},{"key":"2025042507385214000_2009.mar08_1.bcr0920081008.6","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/ICU.0b013e328010a9b5","article-title":"Update on ocular syphilis","volume":"17","author":"Gaudio","year":"2006","journal-title":"Curr Opin Ophthal"},{"doi-asserted-by":"publisher","key":"2025042507385214000_2009.mar08_1.bcr0920081008.7","DOI":"10.1080\/08820530500232092"},{"key":"2025042507385214000_2009.mar08_1.bcr0920081008.8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00006982-199010030-00012","article-title":"Syphilitic disc edema and periphlebitis","volume":"10","author":"Halperin","year":"1990","journal-title":"Retina"},{"doi-asserted-by":"publisher","key":"2025042507385214000_2009.mar08_1.bcr0920081008.9","DOI":"10.1097\/OLQ.0b013e3181644b5e"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.09.2008.1008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:39:00Z","timestamp":1745591940000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.09.2008.1008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":9,"alternative-id":["10.1136\/bcr.09.2008.1008"],"URL":"https:\/\/doi.org\/10.1136\/bcr.09.2008.1008","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}