{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:04:52Z","timestamp":1756425892139,"version":"3.44.0"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterised by epistaxis, telangiectases, and multiorgan vascular dysplasia. Mutations of the <jats:italic>ENG<\/jats:italic> and <jats:italic>ACVRL1<\/jats:italic> genes cause at least 80% of cases. We report the first case of merkeloma found in a patient with HHT carrying an <jats:italic>ENG<\/jats:italic> mutation. We analysed the tumour with immunohistochemical methods using primary antibodies against CD105 (endoglin), TGF-\u03b2, Smad4, CD31 and CD34. Tumour cells were positive for Smad4, weakly positive for TGF-\u03b2, and negative for CD105. Vasal endothelial cells were highly positive for CD105, CD31 and CD34. No remarkable differences between cancer and normal cells in our patient or between the patient\u2019s merkeloma and two control merkelomas were observed. The presence of a merkeloma in an HHT patient could be an occasional association, but to certainly assume it further investigations are needed.<\/jats:p>","DOI":"10.1136\/bcr.09.2009.2251","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T03:48:03Z","timestamp":1265600883000},"page":"bcr0920092251","source":"Crossref","is-referenced-by-count":0,"title":["Immunohistochemical analysis of a merkeloma observed in a patient affected by hereditary haemorrhagic telangiectasia"],"prefix":"10.1136","volume":"2010","author":[{"given":"Elisa","family":"Rossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Boeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Morbini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pagella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Matti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Villanacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Minelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Buscarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Canzonieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Danesino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.030833"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.2","first-page":"S68","article-title":"Merkel cell carcinoma (neuroendocrine carcinoma of the skin)","volume":"115","author":"Smith","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331407"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.4","doi-asserted-by":"publisher","DOI":"10.1038\/ng1294-345"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.5","doi-asserted-by":"publisher","DOI":"10.1038\/ng0696-189"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0187-5"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1203\/00006450-200001000-00008","article-title":"Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin","volume":"47","author":"Cymerman","year":"2000","journal-title":"Pediatr Res"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206813"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.9","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21594"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(03)00181-4"},{"key":"2025082805232754000_2010.feb07_1.bcr0920092251.11","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3280a608a4"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.09.2009.2251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:23:33Z","timestamp":1756383813000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.09.2009.2251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"alternative-id":["10.1136\/bcr.09.2009.2251"],"URL":"https:\/\/doi.org\/10.1136\/bcr.09.2009.2251","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2010]]}}}