{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:25:29Z","timestamp":1789997129922,"version":"4.0.1"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>A case is presented of meningitis in a 7-year-old female child caused by Group A streptococcus (GAS), a rare bacterial cause of meningitis, with a high rate of morbidity (46%) and mortality (10%). GAS is susceptible for empiric antibiotic therapy aimed at the most prevalent pathogens of meningitis. As GAS meningitis is typically associated with ear-nose-throat (ENT) infections, specific search for a reservoir is advised. Bacterial typification often demonstrates M-protein gene sequence type (EMM type) 1.0 associated with upper respiratory tract infections and also severe, invasive GAS infections. Follow-up investigation including neurologic developmental status and audiologic testing is necessary. Although GAS is a very uncommon cause of acute bacterial meningitis in children, high morbidity and mortality have been reported. Being associated with ENT infections, a search for a GAS reservoir is proposed. GASs are susceptible for common empiric antibiotic therapies in meningitis. Follow-up investigation is necessary.<\/jats:p>","DOI":"10.1136\/bcr.10.2011.4896","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T11:29:18Z","timestamp":1321874958000},"page":"bcr1020114896","source":"Crossref","is-referenced-by-count":1,"title":["Group-A-streptococcal meningitis in a 7-year-old child \u2013 a rare pathogen in a non-immune compromised patient"],"prefix":"10.1136","volume":"2011","author":[{"given":"Leonarda Maria (LM)","family":"van Zitteren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niek LA","family":"Arents","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feico","family":"Halbertsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601253340407"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608223350803"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.3","unstructured":"Rijksinstituut voor Volksgezondheid en Milieuhygi\u00ebne. Hersenvliesontsteking. The Netherlands: Nationaal Kompas Volksgezondheid; 4.3 2011."},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.4","unstructured":"Referentie Laboratorium voor Bacteri\u00eble Meningitis. The Netherlands: AMC Amsterdam 2009."},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.5","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00422-08"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.6","doi-asserted-by":"publisher","DOI":"10.1086\/339941"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.7","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-200112000-00007"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.8","doi-asserted-by":"publisher","DOI":"10.1086\/425368"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.9","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.5.1087"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.10","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199912000-00008"},{"key":"2025082804480904000_2011.nov17_1.bcr1020114896.11","first-page":"1578","article-title":"Site-specific manifestations of invasive group A streptococcal disease: type distribution and corresponding patterns of virulence determinants","volume":"188","author":"Vlaminckx","year":"2003","journal-title":"J Clin Microbiol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.10.2011.4896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:48:17Z","timestamp":1756381697000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.10.2011.4896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":11,"alternative-id":["10.1136\/bcr.10.2011.4896"],"URL":"https:\/\/doi.org\/10.1136\/bcr.10.2011.4896","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]}}}