{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:10:38Z","timestamp":1759342238286,"version":"3.40.4"},"reference-count":11,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Chronic neutrophilic leukaemia (CNL) is a rare myeloproliferative disorder of elderly patients characterised by sustained neutrophilia. The diagnosis of CNL requires the exclusion of BCR\/ABL positive chronic myelogenous leukaemia and leukemoid reaction. We present here a case of a 61-year-old Egyptian man with CNL and 21 months of follow-up. The main symptom of our patient was purpura. Splenomegaly, hepatomegaly and lymph node enlargement were not detected at presentation or throughout the patient\u2019s course. Thrombocytopenia was a considerable problem in our patient, causing recurrent bleeding and affecting the hydroxyurea dose adjustment. While hydroxyurea decreased the total leucocytic count, it could not affect the fatal course of the disease. The survival course of our patient extended to 21 months after presentation. The cause of death was attributed to disease progression.<\/jats:p>","DOI":"10.1136\/bcr.11.2008.1277","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T12:33:52Z","timestamp":1245846832000},"page":"bcr1120081277","source":"Crossref","is-referenced-by-count":1,"title":["Chronic neutrophilic leukaemia: an Egyptian case"],"prefix":"10.1136","volume":"2009","author":[{"given":"Ashraf","family":"Elbahrawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Hanafy","family":"Morsy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramadan","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,6,24]]},"reference":[{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.1","unstructured":"Jaffe ES Harris NL Stein H , eds. World Health Organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001: 27\u20138."},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.07.012"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ajcp\/72.2.233","article-title":"Chronic neutrophilic leukemia. Report of two cases and review of literature","volume":"72","author":"You","year":"1979","journal-title":"Am J Clin Pathol"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03234.x"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00321039"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403562"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.7","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.4.292"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF01715131"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.9","first-page":"45","article-title":"Chronic neutrophilic leukemia clinicopathological investigation on Japanese cases: with the questionnaire","volume":"30","author":"Nishinari","year":"1989","journal-title":"Rinsho Ketsueki"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00277-003-0636-y","article-title":"Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma","volume":"82","author":"Nimieri","year":"2003","journal-title":"Ann Hematol"},{"key":"2025042508031421000_2009.jun24_1.bcr1120081277.11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/10428199709114162","article-title":"Clinical and biological aspects of Philadelphia-negative\/BCR-negative chronic myeloid leukemia","volume":"25","author":"Costello","year":"1997","journal-title":"Leuk Lymphoma"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.11.2008.1277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:03:26Z","timestamp":1745593406000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.11.2008.1277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":11,"alternative-id":["10.1136\/bcr.11.2008.1277"],"URL":"https:\/\/doi.org\/10.1136\/bcr.11.2008.1277","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}