{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:17:11Z","timestamp":1760908631017,"version":"3.40.4"},"reference-count":14,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Imatinib, the frontline tyrosine kinase inhibitor (TKI), has revolutionised the management of chronic myeloid leukaemia (CML). Severe hepatotoxicity, although uncommon, can occur with this drug. This tends to subside with dose reduction or cessation, but can recur with reintroduction of the drug. Recurrent severe hepatotoxicity mandates permanent discontinuation of imatinib. This can cause difficulties in the management of CML, more so if the patient cannot afford or get access to alternate therapy. Furthermore, alternate therapy, for example, second-line TKIs, can impose a huge economic burden on a healthcare system. Here, the authors report the case of 20-year-old CML patient who developed recurrent hepatotoxicity with the use of imatinib. Introduction of corticosteroids enabled successful reintroduction of imatinib therapy.<\/jats:p>","DOI":"10.1136\/bcr.11.2010.3516","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T12:38:33Z","timestamp":1298464713000},"page":"bcr1120103516","source":"Crossref","is-referenced-by-count":4,"title":["Recurrent imatinib-induced hepatotoxicity in a chronic myeloid leukaemia patient successfully managed with prednisone: Table 1"],"prefix":"10.1136","volume":"2011","author":[{"given":"Shilpi","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya Raj","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,2,23]]},"reference":[{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.1","DOI":"10.1056\/NEJMoa062867"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.2","DOI":"10.1136\/jcp.2005.027797"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.3","DOI":"10.1182\/blood.V98.6.1708"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.4","DOI":"10.1200\/JCO.2003.11.143"},{"key":"2025042701395704000_2011.feb21_2.bcr1120103516.5","first-page":"935","article-title":"Approval summary for imatinib mesylate capsules in the treatment of chronic myelogenous leukemia","volume":"8","author":"Cohen","year":"2002","journal-title":"Clin Cancer Res"},{"key":"2025042701395704000_2011.feb21_2.bcr1120103516.6","first-page":"ECR27","article-title":"Corticosteroids can reverse severe imatinib-induced hepatotoxicity","volume":"91","author":"Ferrero","year":"2006","journal-title":"Haematologica"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.7","DOI":"10.1038\/sj.leu.2402910"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.8","DOI":"10.1016\/S0399-8320(04)95160-3"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.9","DOI":"10.1080\/10428190600593877"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.10","DOI":"10.3816\/CLM.2008.s.003"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.11","DOI":"10.1016\/S0959-8049(09)70047-4"},{"unstructured":"Nelson R . Nilotinib Shows Better Early Responses Than Imatinib in CML. Medscape Medical News from the American Society of Hematology (ASH) 51st Annual Meeting [Internet]. New York: Medscape, WebMD; 14 December 2009. http:\/\/www.medscape.com\/viewarticle\/713786 (accessed 13 Nov 2010).","key":"2025042701395704000_2011.feb21_2.bcr1120103516.12"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.13","DOI":"10.1532\/IJH97.05034"},{"doi-asserted-by":"publisher","key":"2025042701395704000_2011.feb21_2.bcr1120103516.14","DOI":"10.1080\/10245330600937929"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.11.2010.3516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T08:40:05Z","timestamp":1745743205000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.11.2010.3516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":14,"alternative-id":["10.1136\/bcr.11.2010.3516"],"URL":"https:\/\/doi.org\/10.1136\/bcr.11.2010.3516","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011]]}}}