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She had a dramatic presentation with septic shock and acute lung injury with persistence of pulmonary sepsis postoperatively. The importance of postoperative critical care is illustrated by this case in which a young patient underwent major surgery while septic and haemodynamically unstable. According to our research this is the first case of pulmonary botryomycosis reported in Down\u2019s syndrome and the first case which developed septic shock requiring vasoactive drugs and ventilation in the intensive care unit.<\/jats:p>","DOI":"10.1136\/bcr.11.2010.3527","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T17:15:00Z","timestamp":1305220500000},"page":"bcr1120103527","source":"Crossref","is-referenced-by-count":2,"title":["Primary pulmonary botryomycosis presenting with septic shock and acute lung injury"],"prefix":"10.1136","volume":"2011","author":[{"given":"Hesham","family":"Faisal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atef","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naseem","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,5,12]]},"reference":[{"key":"2025042707352114000_2011.may10_1.bcr1120103527.1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1025"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF02172603","article-title":"Mycosis der Lunge beim Pferde.","volume":"49","author":"Bollinger","year":"1870","journal-title":"Virchows Arch Pathol Anat"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archinte.1913.00060280064006","article-title":"Human botryomycosis of the liver.","volume":"2","author":"Opie","year":"1913","journal-title":"Arch Intern Med"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.4","first-page":"344","article-title":"Les formes actinomycotiques du staphylocoque.","volume":"33","author":"Magrou","year":"1919","journal-title":"Ann Inst Pasteur (Paris)"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01045.x"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010307"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.7","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.8","first-page":"183","article-title":"Primary pulmonary botryomycosis.","volume":"19","author":"Bhatti","year":"2002","journal-title":"Infect Dis"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.9","doi-asserted-by":"crossref","first-page":"332S","DOI":"10.1378\/chest.130.4_MeetingAbstracts.322S-b","article-title":"A case of primary pulmonary botryomycosis in a patient without any underlying illness.","volume":"130","author":"Sayal","year":"2006","journal-title":"Chest"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.10","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07091712"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.11","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1996.0031"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.12","first-page":"204","article-title":"Immunology of Down syndrome: a review.","volume":"7","author":"Ugazio","year":"1990","journal-title":"Am J Med Genet Suppl"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.13","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.12.1068"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.1160"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00596.x"},{"key":"2025042707352114000_2011.may10_1.bcr1120103527.16","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00165-1"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.11.2010.3527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T14:35:28Z","timestamp":1745764528000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.11.2010.3527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,12]]},"references-count":16,"alternative-id":["10.1136\/bcr.11.2010.3527"],"URL":"https:\/\/doi.org\/10.1136\/bcr.11.2010.3527","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2011,5,12]]}}}