{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:35:51Z","timestamp":1768534551724,"version":"3.49.0"},"reference-count":16,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"abstract":"<jats:p>Osteonecrosis of the jaw (ONJ) is a serious side effect in patients receiving intravenous nitrogen-containing bisphosphonates (B). It has also been reported to occur due to oral administration of B. Most cases will appear after receiving B for more than 1 year. The authors report a case of a 67-year-old woman with osteoporosis who had received oral alendronate sodium for 2 years and stopped the treatment due to dyspepsia. 18 months later she was diagnosed with breast cancer and bone metastases. She started a treatment based on aromatase inhibitors and zoledronic acid (Z). She developed ONJ soon after the third administration. She was treated with antibiotics, anti-inflammatories and a chlorexidine colutory. She recovered 3 months later. ONJ secondary to Z may occur also earlier than it was thought in patients with a history of taking oral B.<\/jats:p>","DOI":"10.1136\/bcr.11.2011.5244","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T06:47:16Z","timestamp":1332830836000},"page":"bcr1120115244","source":"Crossref","is-referenced-by-count":2,"title":["Early appearance of osteonecrosis of the jaw after zoledronic acid in a patient with a long history of taking oral bisphosphonates: Figure 1"],"prefix":"10.1136","volume":"2012","author":[{"given":"Esther","family":"U\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,3,27]]},"reference":[{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.14219\/jada.archive.2005.0109","article-title":"Bisphosphonate-associated osteonecrosis of the jaws: a review of current knowledge.","volume":"136","author":"Markiewicz","year":"2005","journal-title":"J Am Dent Assoc"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.2","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.14219\/jada.archive.2005.0108","article-title":"Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper.","volume":"136","author":"Migliorati","year":"2005","journal-title":"J Am Dent Assoc"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.3","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.","volume":"62","author":"Fournier","year":"2002","journal-title":"Cancer Res"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.4","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0707onj"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05768.x"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.08.008"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.8","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0384-2"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2010.05.009"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.10","first-page":"b147","article-title":"Preventive strategies and clinical implications for bisphosphonate-related osteonecrosis of the jaw: a review of 282 patients.","volume":"77","author":"Bonacina","year":"2011","journal-title":"J Can Dent Assoc"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.08.017"},{"key":"2025082722070913000_2012.mar26_1.bcr1120115244.12","doi-asserted-by":"crossref","unstructured":"Lee JJ Cheng SJ Wang YP . refOsteonecrosis of the jaws associated with the use of yearly zoledronic acid: report of 2 cases. 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