{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T15:40:02Z","timestamp":1745595602993,"version":"3.40.4"},"reference-count":13,"publisher":"BMJ","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ Case Reports"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Herpes simplex encephalitis (HSE) is the most frequent cause of sporadic fatal encephalitis in the Western world. Definitive diagnosis by viral PCR of cerebrospinal fluid (CSF) and treatment with aciclovir have improved the prognosis significantly. Nevertheless, the condition is rare and presents with non-specific symptoms that can easily be mistaken for systemic infection or non-infective encephalopathy. We report a case of HSE which was not recognised by four separate doctors, leading to substantial delay in diagnosis and treatment. Our patient presented with fever, headaches, altered behaviour and generalised bradykinesia. This was initially diagnosed as otitis interna (labyrinthitis) and, subsequently, an ischaemic stroke. There was a delay of 10 days in the initiation of aciclovir from symptom onset. MRI and CSF PCR confirmed herpes simplex virus type-1 (HSV-1) infection. The patient improved on aciclovir, but is disabled with word-finding difficulties and cognitive slowing.<\/jats:p>","DOI":"10.1136\/bcr.12.2008.1350","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T09:32:55Z","timestamp":1243848775000},"page":"bcr1220081350","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic delay in a case of herpes simplex encephalitis"],"prefix":"10.1136","volume":"2009","author":[{"given":"Zaid","family":"Shalchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hargroves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Nash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034280"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.2","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.924.575"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2169\/internalmedicine.41.420","article-title":"Acute viral encephalitis: the recent progress","volume":"41","author":"Shoji","year":"2002","journal-title":"Intern Med"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1017\/S0317167100004054","article-title":"Herpes simplex encephalitis","volume":"32","author":"Taylor","year":"2005","journal-title":"Can J Neurol Sci"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1056\/NEJM198601163140303","article-title":"Vidarabine versus acyclovir therapy in herpes simplex encephalitis","volume":"314","author":"Whitley","year":"1986","journal-title":"N Engl J Med"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0770-7"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2005.07.019"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.8","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1097\/00007611-198511000-00022","article-title":"Atypical manifestations of herpes simplex encephalitis","volume":"78","author":"Tashjian","year":"1985","journal-title":"South Med J"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-6723.2005.00765.x"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.10","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-001-1124-8"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01645.x"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.12","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162206000120"},{"key":"2025042507592676000_2009.jun01_1.bcr1220081350.13","doi-asserted-by":"publisher","DOI":"10.1086\/341405"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr.12.2008.1350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T14:59:32Z","timestamp":1745593172000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr.12.2008.1350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":13,"alternative-id":["10.1136\/bcr.12.2008.1350"],"URL":"https:\/\/doi.org\/10.1136\/bcr.12.2008.1350","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2009]]}}}