{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:49:12Z","timestamp":1764240552236,"version":"3.37.3"},"reference-count":30,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate whether baseline vessel density (VD) parameters derived from optical coherence tomography angiography (OCT-A) is associated with the development of glaucomatous visual field (VF) defects in preperimetric glaucoma (PPG) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One eye from each of 200 consecutive PPG patients with a normal standard automated perimetry and OCT-A at baseline was retrospectively analysed. OCT-A was used to measure the circumpapillary VD (cpVD) and the parafoveal and perifoveal VD. The retinal nerve fibre layer (RNFL) and macular ganglion cell-inner plexiform layer thicknesses were measured as reference standards. Two patient groups were stratified based on the development of repeatable glaucomatous VF loss. A Cox proportional hazards model was constructed to determine the predictive ability of OCT-A parameters for VF defects. The correlation between these baseline OCT-A parameters and the rate of global VF sensitivity loss (dB\/year) was calculated using linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a 3.1-year average follow-up period, 18 eyes (9.0%) developed glaucomatous VF defects. At baseline, the lower inferior temporal cpVD (HR (95%\u2009CI)=0.934 (0.883 to 0.988); p=0.017) and thinner inferior RNFL (HR (95%\u2009CI)=0.895 (0.839 to 0.956); p=0.001) were predictive of glaucomatous VF loss. A lower inferior temporal cpVD and thinner RNFL at baseline were associated with faster rate of global VF sensitivity loss (\u03b2=0.015; p=0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In PPG eyes, a lower baseline inferior temporal cpVD is significantly associated with glaucomatous VF defect development and a faster rate of global VF loss.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2021-321025","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T15:31:07Z","timestamp":1661441467000},"page":"1621-1629","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Association of baseline optical coherence tomography angiography with the development of glaucomatous visual field defects in preperimetric glaucoma eyes"],"prefix":"10.1136","volume":"107","author":[{"given":"Jin Yeong","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-3967","authenticated-orcid":false,"given":"Joong Won","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Su","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-1237","authenticated-orcid":false,"given":"Michael S","family":"Kook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"2023102002150964000_107.11.1621.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.05.004"},{"key":"2023102002150964000_107.11.1621.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.01.017"},{"key":"2023102002150964000_107.11.1621.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.07.005"},{"key":"2023102002150964000_107.11.1621.4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ogla.2019.10.001","article-title":"Influence of choroidal microvasculature dropout on the rate of glaucomatous progression: a prospective study","volume":"3","author":"Lee","year":"2020","journal-title":"Ophthalmol Glaucoma"},{"key":"2023102002150964000_107.11.1621.5","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1167\/iovs.16-20287","article-title":"Oct angiography of the peripapillary retina in primary open-angle glaucoma","volume":"57","author":"Lee","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023102002150964000_107.11.1621.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.12.030"},{"key":"2023102002150964000_107.11.1621.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.07.023"},{"key":"2023102002150964000_107.11.1621.8","unstructured":"Anderson DR . 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