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Only eyes with a minimum of four good quality OCT-A and OCT scans of the optic nerve head acquired at least and with a minimum of 2 years follow-up were included. Area and angular circumference of MvD were analysed on en face images. Univariable and multivariable mixed effects models were constructed to identify the factors contributing to MvD area and angular circumference change over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Peripapillary MvD was detected in 53 (58.2%) eyes at baseline and in an additional 17 (18.6%) eyes during follow-up, whereas MvD was not detected in 21 (23.0 %) eyes during the entire follow-up period. In multivariable analysis, worse baseline visual field (VF) mean deviation (MD) (\u00df=0.27, 95%\u2009CI 0.10 to 0.44, p=0.002), greater intraocular pressure (IOP) fluctuations (\u00df=0.86, 95%\u2009CI 0.24 to 1.48, p=0.007), higher peak IOP (\u00df=0.17, 95%\u2009CI \u22120.01 to 0.35, p=0.067) and greater number of IOP lowering medications (\u00df=1.36, 95%\u2009CI 0.67 to 2.05, p&lt;0.001) were associated with faster MvD area enlargement. Worse baseline VF MD and greater IOP fluctuation were also associated with significantly faster MvD circumferential enlargement in multivariable models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Greater IOP fluctuation, higher peak IOP, worse baseline VF MD and greater number of glaucoma medications were significantly associated with MvD enlargement in glaucomatous eyes. The identification of factors associated with MvD enlargement may improve our understanding of the role of choroidal vasculature in glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-321157","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T17:20:55Z","timestamp":1657300855000},"page":"1444-1451","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Factors associated with choroidal microvascular dropout change"],"prefix":"10.1136","volume":"107","author":[{"given":"Eleonora","family":"Micheletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasan","family":"Moghimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-6623","authenticated-orcid":false,"given":"Takashi","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevin","family":"El-Nimri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golnoush","family":"Mahmoudinedzah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Kamalipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Mohammadzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-5224","authenticated-orcid":false,"given":"Linda M","family":"Zangwill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9553-3202","authenticated-orcid":false,"given":"Robert N","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"2023092102150603000_107.10.1444.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16257-0"},{"key":"2023092102150603000_107.10.1444.2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3129\/i08-058","article-title":"Ocular blood flow in glaucoma","volume":"43","author":"Weinreb","year":"2008","journal-title":"Can J Ophthalmol"},{"key":"2023092102150603000_107.10.1444.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"2023092102150603000_107.10.1444.4","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.ophtha.2016.09.002","article-title":"Deep retinal layer microvasculature dropout detected by the optical coherence tomography angiography in glaucoma","volume":"123","author":"Suh","year":"2016","journal-title":"Ophthalmology"},{"key":"2023092102150603000_107.10.1444.5","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001489"},{"key":"2023092102150603000_107.10.1444.6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ajo.2018.01.035","article-title":"Choroidal microvasculature dropout is associated with parafoveal visual field defects in glaucoma","volume":"188","author":"Kwon","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"2023092102150603000_107.10.1444.7","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ophtha.2018.01.016","article-title":"Choroidal microvasculature dropout is associated with progressive retinal nerve fiber layer thinning in glaucoma with disc hemorrhage","volume":"125","author":"Park","year":"2018","journal-title":"Ophthalmology"},{"key":"2023092102150603000_107.10.1444.8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajo.2018.12.007","article-title":"Parapapillary Deep-Layer microvasculature dropout and visual field progression in glaucoma","volume":"200","author":"Kwon","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"2023092102150603000_107.10.1444.9","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-320621"},{"key":"2023092102150603000_107.10.1444.10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ophtha.2017.10.036","article-title":"Central visual field damage and parapapillary choroidal microvasculature dropout in primary open-angle glaucoma","volume":"125","author":"Lee","year":"2018","journal-title":"Ophthalmology"},{"key":"2023092102150603000_107.10.1444.11","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/IJG.0000000000000587","article-title":"Microvascular compromise develops following nerve fiber layer damage in Normal-Tension glaucoma without choroidal vasculature involvement","volume":"26","author":"Lee","year":"2017","journal-title":"J Glaucoma"},{"key":"2023092102150603000_107.10.1444.12","doi-asserted-by":"crossref","unstructured":"Shin JW , Jo YH , Song MK , et al . 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