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Foveal (fVD), parafoveal (pf), perifoveal (perifVD) and whole-image vessel densities (wiVD) of superficial and deep layers, and their corresponding ganglion cell complex (GCC) thicknesses were obtained from OCTA 6\u00d76\u2009mm<jats:sup>2<\/jats:sup>macula scans. Foveal avascular zone (FAZ) area, FAZ circumference and foveal density-300 (FD300) were measured. Correlation between OCT\/OCTA parameters and Logarithm of the Minimum Angle of Resolution VA (logMAR VA) in early and moderate-advanced glaucoma was evaluated with age and Signal Strength Index-adjusted mixed models. Area under receiver operating characteristic (AUC) was used to evaluate discriminative power of OCT\/OCTA for decreased VA (&lt;20\/25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In early glaucoma (80 eyes), no parameter correlated with VA. In moderate-advanced glaucoma (64 eyes), greater FAZ area (\u03b2=0.228) and circumference (\u03b2=0.063) correlated with worse VA (p&lt;0.05), but not FD300. fThinner sectoral and global GCC was associated with worse VA (\u03b2=0.002\u20130.003, p&lt;0.05), except for inferior hemifield perifGCC and wiGCC. For VD, lower superior hemifield superficial perifVD and wiVD (\u03b2=0.007\u20130.008) and deep fVD (\u03b2=0.004) correlated with worse VA (p&lt;0.05). OCT\/OCTA parameters showed modest ability to discriminate decreased VA, with the superior hemifield performing better than the inferior hemifield. In early glaucoma, GCC and VD showed similar discrimination (AUC=0.67\u20130.77). In moderate-advanced glaucoma, fGCC and pfGCC yielded higher AUC (0.75\u20130.81) than VD (AUC=0.63\u20130.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Some macular OCT\/OCTA parameters were associated with VA in moderate-advanced, but not early glaucoma. These structural parameters may help identify glaucoma patients with impaired vision and reduced quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\" xlink:href=\"NCT00221897\">NCT00221897<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-321460","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T17:31:39Z","timestamp":1662744699000},"page":"1652-1657","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Association of macular OCT and OCTA parameters with visual acuity in glaucoma"],"prefix":"10.1136","volume":"107","clinical-trial-number":[{"clinical-trial-number":"nct00221897","registry":"10.18810\/clinical-trials-gov","type":"results"},{"clinical-trial-number":"nct00221897","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-746X","authenticated-orcid":false,"given":"Jo-Hsuan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasan","family":"Moghimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8312-6623","authenticated-orcid":false,"given":"Takashi","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Mohammadzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Kamalipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-5224","authenticated-orcid":false,"given":"Linda 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