{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:48:42Z","timestamp":1788558522472,"version":"build-2803163510"},"reference-count":23,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2022,10,4]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>To compare the outcomes of the Aurolab aqueous drainage implant (AADI) placed in eyes with refractory primary congenital glaucoma (PCG) versus aphakic glaucoma (APG).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Design<\/jats:title>\n<jats:p>Retrospective comparative interventional case series.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n    <jats:p>Case files of consecutive eyes with PCG or APG that underwent AADI surgery between January 2013 and December 2016 and had a minimum 4 years follow-up were extracted from a computerised database. Failure was defined as intraocular pressure (IOP)&gt;21\u2009mm Hg or reduced&lt;20% below baseline on two consecutive follow-up visits after 3 months, IOP\u22645\u2009mm Hg on two consecutive follow-up visits after 3 months, reoperation for glaucoma or a complication, or loss of light perception.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Eighty-nine eyes underwent AADI placement, including 42 eyes (47%) with PCG and 47 eyes (53%) with APG. Both groups were comparable at baseline. At 1\u2009year, the APG group had lower mean IOP (13.6\u00b18.1\u2009mm Hg vs 17.6\u00b17.5\u2009mm Hg, p=0.02) with use of fewer IOP-lowering medications (0.8\u00b11.0 vs 1.5\u00b11.0, p=0.01) than the PCG group. The cumulative failure rate at 4\u2009years was 57% (95% CI 43% to 72%) in PCG versus 40% (95% CI 28% to 56%) in the APG eyes (p=0.11). Eyes with PCG had greater tube-related complications (48% vs 38%, p=0.07) and number of reoperations (40% vs 32%, p=0.02) compared with eyes with APG.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Eyes with APG had relatively better outcomes after AADI placement compared with PCG during 4 years of follow-up. Reoperations accounted for more than 70% of the failures.<\/jats:p>\n<\/jats:sec>","DOI":"10.1136\/bjo-2022-321571","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T17:20:39Z","timestamp":1665681639000},"page":"1823-1827","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Long-term surgical outcomes of Aurolab aqueous drainage implant in pediatric eyes with primary congenital glaucoma versus aphakic glaucoma"],"prefix":"10.1136","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-2884","authenticated-orcid":false,"given":"George 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