{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:48:28Z","timestamp":1791485308503,"version":"4.3.4"},"reference-count":29,"publisher":"BMJ","issue":"10","funder":[{"name":"the Project of Biobank of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["YBKA201907"],"award-info":[{"award-number":["YBKA201907"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802739"],"award-info":[{"award-number":["81802739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>Extranodal marginal zone lymphoma of ocular adnexa (OA-EMZL) is the most frequent type of ocular adnexal lymphomas, with a high rate of disease recurrence. Precise patient stratification based on disease recurrence is understudied. This study aims to identify risk factors of distant recurrence (DR) and local recurrence (LR) to construct a prognostic model optimising rapid decision of therapeutic strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 104 patients diagnosed with OA-EMZL between January 2011 and February 2020 were enrolled. Propensity score matching was performed for DR and LR groups. A nomogram was generated using a multivariate Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After matching, different independent risk factors of DR and LR were identified. Monocyte percentage (p=0.015) and M category &gt;0 (p=0.043) were significant independent risk factors of DR. Epiphora (p&lt;0.001) was the significant independent risk factor of LR. Three factors (monocyte percentage, M category &gt;0, age &gt;60) were integrated into the nomogram to predict the risk of DR. It had a relatively better discriminative ability for distant recurrence-free survival (C-index: 3-year, 0.784; 6-year, 0.801) than IPI score (C-index: 3-year, 0.663; 6-year, 0.673) in the cohort of all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our analyses suggested DR and LR as two distinct prognostic events, and additionally identified novel risk factors of them. The nomogram may serve as a practical tool for the prognostic estimation and rapid decision of therapeutic strategies for patients with OA-EMZL.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-321656","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T17:59:28Z","timestamp":1659376768000},"page":"1560-1566","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Predicting the risk of distant and local recurrence for patients with ocular adnexal extranodal marginal zone lymphoma: a matched case\u2013control study"],"prefix":"10.1136","volume":"107","author":[{"given":"Jiahao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-5697","authenticated-orcid":false,"given":"Yefei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-7451","authenticated-orcid":false,"given":"Renbing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-610X","authenticated-orcid":false,"given":"Yixiong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1904-5367","authenticated-orcid":false,"given":"Xianqun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2023092102150594000_107.10.1560.1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pathol.2019.08.012","article-title":"Marginal zone B-cell lymphoma: lessons from Western and eastern diagnostic approaches","volume":"52","author":"Nakamura","year":"2020","journal-title":"Pathology"},{"key":"2023092102150594000_107.10.1560.2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10238-017-0474-1","article-title":"Ocular adnexal marginal zone lymphoma of mucosa-associated lymphoid tissue","volume":"18","author":"Kalogeropoulos","year":"2018","journal-title":"Clin Exp Med"},{"key":"2023092102150594000_107.10.1560.3","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314008"},{"key":"2023092102150594000_107.10.1560.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.01.040"},{"key":"2023092102150594000_107.10.1560.5","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/annonc\/mdx025","article-title":"Long-term outcome of 487 patients with early-stage extra-nodal marginal zone lymphoma","volume":"28","author":"Teckie","year":"2017","journal-title":"Ann Oncol"},{"key":"2023092102150594000_107.10.1560.6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2539"},{"key":"2023092102150594000_107.10.1560.7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/jjco\/hyz044","article-title":"Long-term outcome, relapse patterns, and toxicity after radiotherapy for orbital mucosa-associated lymphoid tissue lymphoma: implications for radiotherapy optimization","volume":"49","author":"Lee","year":"2019","journal-title":"Jpn J Clin Oncol"},{"key":"2023092102150594000_107.10.1560.8","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-315875"},{"key":"2023092102150594000_107.10.1560.9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/bjh.17411","article-title":"The limited role of comprehensive staging work-up in ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type (MALToma) with excellent prognosis","volume":"193","author":"Chae","year":"2021","journal-title":"Br J Haematol"},{"key":"2023092102150594000_107.10.1560.10","unstructured":"MB A , SB E , FL G . 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