{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:28:34Z","timestamp":1793042914373,"version":"4.5.0"},"reference-count":50,"publisher":"BMJ","issue":"1","funder":[{"name":"the Private Schools of Japan, JSPS","award":["20K09810"],"award-info":[{"award-number":["20K09810"]}]},{"name":"the Private Schools of Japan, JSPS","award":["20K22985"],"award-info":[{"award-number":["20K22985"]}]},{"name":"the Private Schools of Japan, JSPS","award":["21K16884"],"award-info":[{"award-number":["21K16884"]}]},{"name":"the Private Schools of Japan, JSPS","award":["21K20996"],"award-info":[{"award-number":["21K20996"]}]},{"name":"the Private Schools of Japan, JSPS","award":["21K20997"],"award-info":[{"award-number":["21K20997"]}]},{"name":"Grant-in-Aid for Special Research in Subsidies for ordinary expenses of private schools from The Promotion and Mutual Aid Corporation for the Private Schools of Japan","award":["Grant Number: none"],"award-info":[{"award-number":["Grant Number: none"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2022,9,8]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>This study aimed to assess the efficacy and sterility of stored platelet-rich plasma (PRP) eye-drops for corneal epithelial wound healing compared with those of autologous serum (AS) eye-drops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      At our single institution, PRP and AS eye-drops were prepared using peripheral blood obtained from six healthy volunteers and stored at 4\u00b0C. Platelet and leucocyte counts and transforming growth factor (TGF)-\u03b21, epidermal growth factor (EGF), and fibronectin levels were assessed during storage for up to 4 weeks. Sterility was assessed by culturing 4-week poststorage samples. PRP, AS, and phosphate-buffered saline (PBS) eye-drop efficacies were compared using corneal epithelial wound healing assays\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      and monitoring wound areas under a microscope every 3\u2009hours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher platelet and lower leucocyte counts were seen in PRP than in whole blood on the day of preparation. After storage, TGF-\u03b21, EGF, and fibronectin levels were significantly higher in PRP than in AS eye-drops.\n                      <jats:italic>In vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      , PRP eye-drops used on the day of preparation significantly promoted corneal epithelial wound healing compared with PBS. Moreover, PRP eye-drops stored for 4 weeks significantly promoted corneal wound healing compared with PBS and AS eye-drops.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PRP eye-drops stored at 4\u00b0C for 4 weeks promoted corneal epithelial wound healing with higher levels of growth factors than those observed in AS eye-drops, while maintaining sterility, suggesting that this preparation satisfies the unmet medical needs in the treatment of refractory keratoconjunctival epithelial disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2022-322068","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T13:21:13Z","timestamp":1664198473000},"page":"37-44","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Biological effects of stored 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