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It is unclear why tumours cause more injury to crossing nasal fibres, thereby giving rise to temporal visual field loss in each eye. To address this issue, the course of fibres through the optic chiasm was examined following injection of a different fluorescent tracer into each eye of a monkey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Under general anaesthesia, cholera toxin subunit B\u2014Alexa Fluor 488 was injected into the right eye and cholera toxin subunit B\u2014Alexa Fluor 594 was injected into the left eye of a single normal adult male rhesus monkey. After a week\u2019s survival for anterograde transport, serial coronal sections through the primary optic pathway were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A zone within the core of the anterior and mid portions of the optic chiasm was comprised entirely of crossing fibres. This zone of decussation was delineated by segregated, interwoven sheets of green (right eye) and red (left eye) fibres. It expanded steadily to fill more of the optic chiasm as fibres coursed posteriorly towards the optic tracts. Eventually, crossed fibres became completely intermingled with uncrossed fibres, so that ocular separation was lost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A distinct, central compartment located within the anterior two-thirds of the optic chiasm contains only crossing fibres. Sellar tumours focus their compressive force on this portion of the structure, explaining why they so often produce visual field loss in the temporal fields.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-322235","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T18:20:46Z","timestamp":1670264446000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Decussating axons segregate within the anterior core of the primate optic chiasm"],"prefix":"10.1136","volume":"107","author":[{"given":"Jonathan C","family":"Horton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla D","family":"Dilbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Economides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"2023032202150706000_107.4.447.1","doi-asserted-by":"crossref","unstructured":"Newton I . 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