{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:27:00Z","timestamp":1776731220892,"version":"3.51.2"},"reference-count":33,"publisher":"BMJ","issue":"3","funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1R01 EY014943"],"award-info":[{"award-number":["1R01 EY014943"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["1R21 EY032592-01"],"award-info":[{"award-number":["1R21 EY032592-01"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Unrestricted department funds"],"award-info":[{"award-number":["Unrestricted department funds"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,2,9]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Tertiary care academic centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicentre retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was used to gather clinical data. Multivariable logistic regression models with adjustment for intereye correlations were performed to evaluate the prognostic factors for VA outcomes. Main outcome measure was VA after cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Uveitic eyes independent of anatomical location showed improved VA from baseline (mean 20\/200) to within 3 months (mean 20\/63) of cataract surgery and maintained through at least 5 years of follow-up (mean 20\/63). Eyes that achieved 20\/40 or better VA at 1\u2009year were more likely to have scleritis (OR=1.34, p&lt;0.0001) or anterior uveitis (OR=2.2, p&lt;0.0001), VA 20\/50 to 20\/80 (OR 4.76 as compared with worse than 20\/200, p&lt;0.0001) preoperatively, inactive uveitis (OR=1.49, p=0.03), have undergone phacoemulsification (OR=1.45 as compared with extracapsular cataract extraction, p=0.04) or have had intraocular lens placement (OR=2.13, p=0.01). Adults had better VA immediately after surgery, with only 39% (57\/146) paediatric eyes at 20\/40 or better at 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that adult and paediatric eyes with uveitis typically have improved VA following cataract surgery and remain stable thereafter for at least 5 years.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-322236","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T18:26:00Z","timestamp":1677003960000},"page":"380-385","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease"],"prefix":"10.1136","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-8568","authenticated-orcid":false,"given":"Sapna","family":"Gangaputra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Newcomb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Armour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-4072","authenticated-orcid":false,"given":"Dongseok","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-1355","authenticated-orcid":false,"given":"Gui-shuang","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Groth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hosne","family":"Begum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonetta","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pichaporn","family":"Artornsombudh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebenezer","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirali","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-9798","authenticated-orcid":false,"given":"Stephen","family":"Foster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Jabs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Levy-Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Nussenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H Nida","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Suhler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Thorne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Dreger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanine","family":"Buchanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Kempen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"2024022109050597000_108.3.380.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163549"},{"key":"2024022109050597000_108.3.380.2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ajo.2021.02.032","article-title":"Risk of cataract in intermediate uveitis","volume":"229","author":"Minkus","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"2024022109050597000_108.3.380.3","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.ophtha.2020.01.036","article-title":"Risk of cataract development among children with juvenile idiopathic arthritis-related uveitis treated with topical corticosteroids","volume":"127","author":"Thorne","year":"2020","journal-title":"Ophthalmology"},{"key":"2024022109050597000_108.3.380.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.027"},{"key":"2024022109050597000_108.3.380.5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ophtha.2015.09.022","article-title":"Cataract surgery outcomes in uveitis: the multicenter uveitis steroid treatment trial","volume":"123","author":"Sen","year":"2016","journal-title":"Ophthalmology"},{"key":"2024022109050597000_108.3.380.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00160-3"},{"key":"2024022109050597000_108.3.380.7","doi-asserted-by":"crossref","first-page":"5481609","DOI":"10.1155\/2021\/5481609","article-title":"Cataract surgery with or without intraocular lens implantation in pediatric uveitis: a systematic review with meta-analyses","volume":"2021","author":"Schmidt","year":"2021","journal-title":"J Ophthalmol"},{"key":"2024022109050597000_108.3.380.8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/09286580701585892","article-title":"Methods for identifying long-term adverse effects of treatment in patients with eye diseases: the systemic immunosuppressive therapy for eye diseases (site) cohort study","volume":"15","author":"Kempen","year":"2008","journal-title":"Ophthalmic Epidemiol"},{"key":"2024022109050597000_108.3.380.9","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2480","article-title":"Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study","volume":"339","author":"Kempen","year":"2009","journal-title":"BMJ"},{"key":"2024022109050597000_108.3.380.10","article-title":"Risk of overall and cancer mortality after immunosuppression of patients with non-infectious ocular inflammatory diseases","volume":"60","author":"Kempen","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024022109050597000_108.3.380.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"2024022109050597000_108.3.380.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(82)90197-0"},{"key":"2024022109050597000_108.3.380.13","first-page":"17","article-title":"Visual acuity outcome over time in non-infectious uveitis","volume":"10","author":"Pistilli","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"2024022109050597000_108.3.380.14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ajo.2014.06.018","article-title":"Outcomes of cataract surgery in patients with uveitis: a systematic review and meta-analysis","volume":"158","author":"Mehta","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"2024022109050597000_108.3.380.15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00055735-199602000-00003","article-title":"Cataract surgery in patients with uveitis","volume":"7","author":"Rojas","year":"1996","journal-title":"Curr Opin Ophthalmol"},{"key":"2024022109050597000_108.3.380.16","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s40123-021-00363-0","article-title":"Timing of quiescence and uveitis recurrences after cataract surgery in patients with a history of uveitis","volume":"10","author":"Rohl","year":"2021","journal-title":"Ophthalmol Ther"},{"key":"2024022109050597000_108.3.380.17","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ajo.2015.09.017","article-title":"Factors predicting visual acuity outcome in intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment (must) trial","volume":"160","author":"Kempen","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"2024022109050597000_108.3.380.18","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00417-017-3658-1","article-title":"Outcomes of cataract surgery with\/without vitrectomy in patients with pars planitis and immunosuppressive therapy","volume":"255","author":"Albavera-Giles","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2024022109050597000_108.3.380.19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11926-011-0229-z","article-title":"Prevention and management of cataracts in children with juvenile idiopathic arthritis-associated uveitis","volume":"14","author":"Angeles-Han","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"2024022109050597000_108.3.380.20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/09273948.2016.1213855","article-title":"Cataract surgery with primary lens implantation in children with chronic uveitis","volume":"26","author":"Guindolet","year":"2018","journal-title":"Ocul Immunol Inflamm"},{"key":"2024022109050597000_108.3.380.21","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10112437","article-title":"Cataract surgery with intraocular lens implantation in juvenile idiopathic arthritis-associated uveitis: outcomes in the era of biological therapy","volume":"10","author":"Bolletta","year":"2021","journal-title":"J Clin Med"},{"key":"2024022109050597000_108.3.380.22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1001\/jamaophthalmol.2021.6176","article-title":"Visual acuity and ophthalmic outcomes 5 years after cataract surgery among children younger than 13 years","volume":"140","author":"Repka","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"2024022109050597000_108.3.380.23","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090140115033"},{"key":"2024022109050597000_108.3.380.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2012.11.026"},{"key":"2024022109050597000_108.3.380.25","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ajo.2015.09.028","article-title":"How big data informs us about cataract surgery: the LXXII edward jackson memorial lecture","volume":"160","author":"Coleman","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"2024022109050597000_108.3.380.26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/jamaophthalmol.2021.2032","article-title":"Refractive outcomes after immediate sequential vs delayed sequential bilateral cataract surgery","volume":"139","author":"Owen","year":"2021","journal-title":"JAMA Ophthalmol"},{"key":"2024022109050597000_108.3.380.27","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamaophthalmol.2019.1220","article-title":"Visual acuity and ophthalmic outcomes in the year after cataract surgery among children younger than 13 years","volume":"137","author":"Repka","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"2024022109050597000_108.3.380.28","doi-asserted-by":"crossref","DOI":"10.1186\/s12348-016-0079-y","article-title":"Controversies in intraocular lens implantation in pediatric uveitis","volume":"6","author":"Phatak","year":"2016","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"2024022109050597000_108.3.380.29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/09273948.2013.834062","article-title":"Cataract management in juvenile idiopathic arthritis: simultaneous versus secondary intraocular lens implantation","volume":"22","author":"Magli","year":"2014","journal-title":"Ocul Immunol Inflamm"},{"key":"2024022109050597000_108.3.380.30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/S0161-6420(92)31818-4","article-title":"Extracapsular cataract extraction and posterior chamber intraocular lens implantation in uveitis patients","volume":"99","author":"Foster","year":"1992","journal-title":"Ophthalmology"},{"key":"2024022109050597000_108.3.380.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)99051-0"},{"key":"2024022109050597000_108.3.380.32","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/08820538.2017.1353815","article-title":"Cataract surgery complications in uveitis patients: a review article","volume":"33","author":"Llop","year":"2018","journal-title":"Semin Ophthalmol"},{"key":"2024022109050597000_108.3.380.33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jcjo.2016.10.007","article-title":"Ten-year retrospective review of outcomes following phacoemulsification with intraocular lens implantation in patients with pre-existing uveitis","volume":"52","author":"Chiu","year":"2017","journal-title":"Can J Ophthalmol"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2022-322236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T17:10:24Z","timestamp":1708535424000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2022-322236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,21]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2,21]]},"published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1136\/bjo-2022-322236"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2022-322236","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"value":"0007-1161","type":"print"},{"value":"1468-2079","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,21]]}}}