{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:00:19Z","timestamp":1756810819449,"version":"3.37.3"},"reference-count":38,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["05162836"],"award-info":[{"award-number":["05162836"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the rates of peripapillary vessel density (pVD) loss and retinal nerve fibre layer (RNFL) thinning in normal tension glaucoma (NTG) and primary angle closure glaucoma (PACG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline age and severity-matched NTG and PACG eyes (75 eyes of 60 patients for each subtype) were observed longitudinally. All participants\u2019 RNFL thickness were measured by optical coherence tomography (OCT); pVD were measured by swept-source OCT-angiography (OCT-A) and quantified by a customised MATLAB program. The rate of pVD loss and RNFL thinning were estimated by linear mixed-effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NTG eyes had significant pVD loss in all sectors (p\u22640.05) while PACG eyes\u2019 pVD loss was borderline significant in the global region (p=0.05). Significant RNFL thinning was detected in the inferotemporal and superonasal regions of both groups, and the superotemporal region in the NTG group (all p\u22640.02). NTG had faster rate of pVD loss in the global (difference (95% CI) \u22121.08 (\u22121.90 to \u20130.27) %\/year), temporal (\u22121.57 (\u22122.91 to \u20130.23) %\/year) and superotemporal (\u22121.46 (\u22122.65 to \u20130.26) %\/year) regions than PACG (all p<jats:italic>\u2264<\/jats:italic>0.02), without significant difference of the rate of RNFL thinning. A lower baseline mean deviation (MD) was associated with a faster rate of global pVD loss, while a lower baseline pVD was associated with a slower rate of global pVD loss in multivariable analyses (both p\u22640.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NTG had more extensive and faster rate of pVD loss than PACG. Baseline global pVD and MD were independently associated with the rate of pVD loss in NTG.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-322336","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:20:12Z","timestamp":1671819612000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal change of peripapillary vessel density and retinal nerve fibre layer thickness in normal tension and primary angle closure glaucoma"],"prefix":"10.1136","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-8806","authenticated-orcid":false,"given":"Poemen PuiMan","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyue","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-1819","authenticated-orcid":false,"given":"Carol Y","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-8914","authenticated-orcid":false,"given":"Marco","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Pui","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-6907","authenticated-orcid":false,"given":"Clement C","family":"Tham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"2024012903300914000_108.2.195.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"2024012903300914000_108.2.195.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00272-4"},{"key":"2024012903300914000_108.2.195.3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajo.2018.10.017","article-title":"Prevalence of Normal-Tension glaucoma in the Chinese population: a systematic review and meta-analysis","volume":"199","author":"Zhao","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"2024012903300914000_108.2.195.4","doi-asserted-by":"crossref","first-page":"624179","DOI":"10.3389\/fmed.2020.624179","article-title":"Prevalence of primary angle closure glaucoma in the last 20 years: a meta-analysis and systematic review","volume":"7","author":"Zhang","year":"2021","journal-title":"Front Med"},{"key":"2024012903300914000_108.2.195.5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/01.APO.0000605096.48529.9c","article-title":"Latest developments in normal-pressure glaucoma: diagnosis, epidemiology, genetics, etiology, causes and mechanisms to management","volume":"8","author":"Lee","year":"2019","journal-title":"Asia Pac J Ophthalmol"},{"key":"2024012903300914000_108.2.195.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"2024012903300914000_108.2.195.7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.6.720"},{"key":"2024012903300914000_108.2.195.8","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/jamaophthalmol.2015.2225","article-title":"Optical coherence tomography angiography of the peripapillary retina in glaucoma","volume":"133","author":"Liu","year":"2015","journal-title":"JAMA Ophthalmol"},{"key":"2024012903300914000_108.2.195.9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18944"},{"key":"2024012903300914000_108.2.195.10","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.ophtha.2016.08.041","article-title":"Relationship between optical coherence tomography angiography vessel density and severity of visual field loss in glaucoma","volume":"123","author":"Yarmohammadi","year":"2016","journal-title":"Ophthalmology"},{"key":"2024012903300914000_108.2.195.11","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-62633-4","article-title":"Optic disc and macular vessel density measured by optical coherence tomography angiography in open-angle and angle-closure glaucoma","volume":"10","author":"Hou","year":"2020","journal-title":"Sci Rep"},{"key":"2024012903300914000_108.2.195.12","doi-asserted-by":"crossref","first-page":"5862","DOI":"10.1167\/iovs.18-25423","article-title":"The relationship between peripapillary vascular density and visual field sensitivity in primary open-angle and angle-closure glaucoma","volume":"59","author":"Jo","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2024012903300914000_108.2.195.13","doi-asserted-by":"crossref","unstructured":"Shen R , Wang YM , Cheung CY , et al . 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