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We then performed digital volume correlation analysis to quantify IOP-induced and gaze-induced ONH tissue deformations and strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across all subjects, adduction generated high effective strain (4.4%\u00b12.3%) in the LC tissue with no significant difference (p&gt;0.05) with those induced by IOP elevation (4.5%\u00b12.4%); while abduction generated significantly lower (p=0.01) effective strain (3.1%\u00b11.9%). The lamina cribrosa (LC) of HTG subjects exhibited significantly higher effective strain than those of NTG subjects under IOP elevation (HTG: 4.6%\u00b11.7%\u2009vs NTG: 4.1%\u00b11.5%, p&lt;0.05). Conversely, the LC of NTG subjects exhibited significantly higher effective strain than those of HTG subjects under adduction (NTG: 4.9%\u00b11.9%\u2009vs HTG: 4.0%\u00b11.4%, p&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that NTG subjects experienced higher strains due to adduction than HTG subjects, while HTG subjects experienced higher strain due to IOP elevation than NTG subjects\u2014and that these differences were most pronounced in the LC tissue.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2022-322461","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T13:20:12Z","timestamp":1680528012000},"page":"bjo-2022-322461","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Adduction induces large optic nerve head deformations in 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