{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:30:25Z","timestamp":1740133825889,"version":"3.37.3"},"reference-count":33,"publisher":"BMJ","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Key Project of Internet Cross-Border Intergration Innovation and Technology of Tianjin","award":["18ZXRHSY00210"],"award-info":[{"award-number":["18ZXRHSY00210"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171085"],"award-info":[{"award-number":["82171085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project","award":["TJYXZDXK-037A"],"award-info":[{"award-number":["TJYXZDXK-037A"]}]},{"name":"Science and Technology Project of Tianjin Binhai New Area Health Commission","award":["2022BWKQ011"],"award-info":[{"award-number":["2022BWKQ011"]}]},{"DOI":"10.13039\/501100006606","name":"The Natural Science Foundation of Tianjin City","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the role of papillary vitreous detachment in the pathogenesis of non-arteritic anterior ischaemic optic neuropathy (NAION) by comparing the features of vitreopapillary interface between NAION patients and normal individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 22 acute NAION patients (25 eyes), 21 non-acute NAION patients (23 eyes) and 23 normal individuals (34 eyes). All study participants underwent swept-source optical coherence tomography to assess the vitreopapillary interface, peripapillary wrinkles and peripapillary superficial vessel protrusion. The statistical correlations between peripapillary superficial vessel protrusion measurements and NAION were analysed. Two NAION patients underwent standard pars plana vitrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Incomplete papillary vitreous detachment was noted in all acute NAION patients. The prevalence of peripapillary wrinkles was 68% (17\/25), 30% (7\/23) and 0% (0\/34), and the prevalence of peripapillary superficial vessel protrusion was 44% (11\/25), 91% (21\/23) and 0% (0\/34) in the acute, non-acute NAION and control groups, respectively. The prevalence of peripapillary superficial vessel protrusion was 88.9% in the eyes without retinal nerve fibre layer thinning. Furthermore, the number of peripapillary superficial vessel protrusions in the superior quadrant was significantly higher than that in the other quadrants in eyes with NAION, consistent with the more damaged visual field defect regions. Peripapillary wrinkles and visual field defects in two patients with NAION were significantly attenuated within 1\u2009week and 1\u2009month after the release of vitreous connections, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peripapillary wrinkles and superficial vessel protrusion may be signs of papillary vitreous detachment-related traction in NAION. Papillary vitreous detachment may play an important role in NAION pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2022-322726","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T17:20:57Z","timestamp":1681406457000},"page":"bjo-2022-322726","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Papillary vitreous detachment as a possible accomplice in non-arteritic anterior ischaemic optic neuropathy"],"prefix":"10.1136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-8053","authenticated-orcid":false,"given":"Dong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingli","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuntao","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4898-4152","authenticated-orcid":false,"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongguo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-2797","authenticated-orcid":false,"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"2023041310200615000_bjo-2022-322726v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70999-7"},{"key":"2023041310200615000_bjo-2022-322726v1.2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.62.4.42","article-title":"Follow-up of nonarteritic anterior ischemic optic neuropathy with optical coherence tomography angiography","volume":"62","author":"Augstburger","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2023041310200615000_bjo-2022-322726v1.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413352"},{"key":"2023041310200615000_bjo-2022-322726v1.4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/WNO.0000000000000870","article-title":"Unraveling the enigma of nonarteritic anterior ischemic optic neuropathy","volume":"39","author":"Rizzo","year":"2019","journal-title":"J Neuroophthalmol"},{"key":"2023041310200615000_bjo-2022-322726v1.5","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-200306000-00012"},{"key":"2023041310200615000_bjo-2022-322726v1.6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/WNO.0000000000001464","article-title":"Does vitreopapillary traction cause nonarteritic anterior ischemic optic neuropathy?","volume":"42","author":"Parsa","year":"2022","journal-title":"J Neuroophthalmol"},{"key":"2023041310200615000_bjo-2022-322726v1.7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ophtha.2014.11.011","article-title":"Nonarteritic anterior ischemic optic neuropathy (NAION): a misnomer. 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