{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:01:30Z","timestamp":1792011690851,"version":"4.4.0"},"reference-count":35,"publisher":"BMJ","issue":"1","funder":[{"name":"Ministry of Science and Technology Research Grant","award":["MOST 109-2314-B-182A-019-MY3"],"award-info":[{"award-number":["MOST 109-2314-B-182A-019-MY3"]}]},{"name":"Chang Gung Memorial Hospital Research Grants","award":["CMRPG3M0131 and CMRPG3L0151"],"award-info":[{"award-number":["CMRPG3M0131 and CMRPG3L0151"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,6,2]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>The aims of this study is to evaluate the anatomic, visual outcomes and associated prognostic factors in patients with advanced retinopathy of prematurity (ROP) following vitrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of patients with ROP who underwent vitrectomy from 2005 to 2016 was conducted. All the patients had a follow-up period of at least 5 years. Univariate and multivariable logistic regression analyses were used to explore the factors related to unfavourable outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 81 eyes of 51 patients were included. The mean age at last follow-up was 10.2 years. The anatomic success rate was 96.3% (26\/27) for stage 4A, 90.9% (20\/22) for stage 4B and 31.3% (10\/32) for stage 5 ROP (p&lt;0.01). The mean logMAR best corrected visual acuity of the stage-4A eyes was the highest, followed by those of stage-4B and stage-5 eyes (0.8, 1.5 and 2.6 for stages 4A, 4B and 5, respectively; p&lt;0.01). High myopia (\u2264 \u22125.0\u2009D) was noted in 70.8% and 71.4% of stage-4A and stage-4B eyes, respectively. Cataract was the most common complication (25.9%), followed by corneal opacity (17.3%), strabismus (16.1%), and phthisis (16.1%). Stage of the disease was a poor prognostic factor in all vitrectomised eyes (p&lt;0.01). Vitrectomy combined lensectomy was a significant predictor for poor anatomic outcomes for stage-4 eyes (p=0.03). Presence of plus disease was also a possible factor affecting the surgical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The long-term surgical outcomes of the eyes with stage 4A and 4B ROP were favourable. Management of stage 5 ROP remained challenging.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-323723","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T17:25:23Z","timestamp":1728321923000},"page":"126-132","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term surgical outcomes and prognostic factors for advanced-stage retinopathy of prematurity after vitrectomy"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1274-0706","authenticated-orcid":false,"given":"Yin-Hsi","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-6530","authenticated-orcid":false,"given":"Eugene 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