{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:27:42Z","timestamp":1787909262739,"version":"build-2784847793"},"reference-count":47,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070994"],"award-info":[{"award-number":["82070994"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,11,5]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the long-term effect of orthokeratology (ortho-k) on the choroidal thickness and choroidal contour in myopic children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were from a conducted 2-year randomised clinical trial. Children (n=80) aged 8\u201312 years with spherical equivalent refraction of \u22121.00 to \u22126.00D were randomly assigned to the control group (n=40) and ortho-k group (n=40). Optical coherence tomography images were collected at the baseline, 1-month, 6-month, 12-month, 18-month and 24-month visits, then the choroidal thickness and choroid contour were calculated. Axial length (AL) and other ocular biometrics were also measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 2\u2009years, in the control group, the choroidal thickness became thinning and the choroidal contour became prolate with time at all visits (all p<jats:italic>&lt;<\/jats:italic>0.001). Ortho-k can improve the choroidal thickness (all p<jats:italic>&lt;<\/jats:italic>0.001) and maintain the choroidal contour at all visits (all p<jats:italic>&lt;<\/jats:italic>0.05). In the ortho-k group, the choroidal contour was less changed in the temporal than nasal (p<jats:italic>=<\/jats:italic>0.008), and the choroidal thickness was more thickening in the temporal 3\u2009mm (p<jats:italic>&lt;<\/jats:italic>0.001). Two-year change in choroidal thickness was significantly associated with the 2-year AL change in the control group (r=\u22120.52, p<jats:italic>&lt;<\/jats:italic>0.001), however, this trend was broken by ortho-k (r=\u22120.05, p<jats:italic>=<\/jats:italic>0.342). After being adjusted by other variables in the multivariable regression model, the effect of ortho-k on choroidal thickness was stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the current 2-year prospective study, ortho-k can improve the choroidal thickness and maintain the choroidal contour, but this effect diminished in a long term. Further study with larger sample size and longer follow-up is warranted to refine this issue.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-323764","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T18:20:18Z","timestamp":1701886818000},"page":"1067-1074","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Long-term effect of orthokeratology on choroidal thickness and choroidal contour in myopic 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