{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:28:40Z","timestamp":1776954520479,"version":"3.51.4"},"reference-count":24,"publisher":"BMJ","issue":"6","funder":[{"name":"Shanghai Science and Technology Commission Research Grant","award":["20DZ2270800"],"award-info":[{"award-number":["20DZ2270800"]}]},{"name":"Shanghai Science and Technology Commission Research Grant","award":["23YF1422400"],"award-info":[{"award-number":["23YF1422400"]}]},{"name":"Shanghai Science and Technology Commission Research Grant","award":["23ZR1438400"],"award-info":[{"award-number":["23ZR1438400"]}]},{"name":"the Project of Biobank of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["YBKA201907"],"award-info":[{"award-number":["YBKA201907"]}]},{"name":"the Project of Biobank of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["YBKA202208"],"award-info":[{"award-number":["YBKA202208"]}]},{"name":"Shanghai Health Commission","award":["2022ZZ01003"],"award-info":[{"award-number":["2022ZZ01003"]}]},{"name":"Cross-disciplinary Research Fund of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["JYJC202210"],"award-info":[{"award-number":["JYJC202210"]}]},{"name":"Cross-disciplinary Research Fund of Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine","award":["YG2023QNB15"],"award-info":[{"award-number":["YG2023QNB15"]}]},{"name":"Shanghai Key Clinical Specialty","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-Level Local Universities in Shanghai","doi-asserted-by":"crossref","award":["SHSMU-ZDCX20210902"],"award-info":[{"award-number":["SHSMU-ZDCX20210902"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-Level Local Universities in Shanghai","doi-asserted-by":"crossref","award":["SHSMUZDCX20210900"],"award-info":[{"award-number":["SHSMUZDCX20210900"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,6,26]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Adenomas of the ciliary body epithelium, including adenoma of the pigmented ciliary body epithelium (APCE) and adenoma of the non-pigmented ciliary body epithelium (ANPCE), are extremely rare, and most knowledge about them comes from sporadic case reports. The purpose of this study was to provide a comprehensive understanding of adenomas of the ciliary body epithelium and to identify the similarities and differences between APCE and ANPCE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective case series comprising data from 41 patients obtained from retrieved publications and five cases diagnosed at the Shanghai Ninth People\u2019s Hospital. The clinicopathological features, treatment and prognosis of APCE and ANPCE were compared using the non-parametric rank sum test, t-test and the \u03c7<jats:sup>2<\/jats:sup>test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical and histopathological features and treatment were analogous between APCE (n=23) and ANPCE (n=23). The overall visual prognosis associated with the two tumours was good, with 63% of the patients having stable or improved vision after treatment. Enucleation was the primary cause of eventual vision loss (three in APCE vs two in ANPCE, p=0.001). Notably, iris invasion was commonly observed in patients with APCE (six in APCE vs zero in ANPCE, p=0.014), and iris invasion was associated with decreased vision eventually (p=0.003). Tumour size was irrelevant to the vision outcome (p=0.65). Metastasis or recurrence did not occur in any of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In most cases, the clinicopathological features of ANPCE and APCE were similar. Iris invasion was commonly observed in patients with APCE, which was associated with poor visual prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-323845","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T17:20:19Z","timestamp":1689096019000},"page":"826-832","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Adenomas of the ciliary body epithelium: clinics, histopathology and 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