{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:34:41Z","timestamp":1791819281565,"version":"4.3.4"},"reference-count":23,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,10,4]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite increasing evidence shows that optimising ocular surface before cataract surgery is fundamental in patients with pre-existing dry eye disease (DED) to achieve the desired postoperative outcomes, the prophylactic treatment of healthy patients undergoing surgery aiming at preventing iatrogenic DED is worth investigating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, interventional, randomised, controlled, double-masked clinical trial. Patients were randomly assigned 1:1 to receive either low-level light therapy (LLLT) or sham treatment (LLLT with a power output &lt;30%). Patients underwent two treatment sessions: 7\u00b12\u2009days before cataract surgery (T0) and 7\u00b12\u2009days after (T1). Outcome measures evaluated 30\u00b14 days after surgery (T2) included Ocular Surface Disease Index (OSDI) questionnaire, non-invasive break-up time (NIBUT), tear meniscus height, meibomian gland loss (MGL) and redness score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 153 patients randomised to receive LLLT (n=73) or sham treatment (n=80), 131 (70 men, 61 women, mean age 73.53\u00b17.29 years) completed regularly the study. Patients treated with LLLT had significantly lower OSDI scores compared with controls at T1 and T2 (respectively, 7.2\u00b18.8 vs 14.8\u00b113.0\u2009and 9.0\u00b19.0 vs 18.2\u00b117.9; both p&lt;0.001), higher NIBUT values at T2 (12.5\u00b16.6 vs 9.0\u00b17.8; p=0.007) and lower MGL Meiboscore values at T1 (1.59\u00b10.70 vs 1.26\u00b10.69; p=0.008). Unlike controls, patients treated with LLLT had significantly lower OSDI scores and higher NIBUT values at T2 compared with T0 (respectively, 9.0\u00b19.0 vs 21.2\u00b116.1; p&lt;0.001\u2009and 12.5\u00b16.6 vs 9.7\u00b17.2; p=0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two sessions of LLLT performed before and after cataract surgery were effective in ameliorating tear film stability and ocular discomfort symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05754437\">NCT05754437<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-323920","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T12:45:18Z","timestamp":1698410718000},"page":"1172-1176","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Outcomes of low-level light therapy before and after cataract surgery for the prophylaxis of postoperative dry eye: a prospective randomised double-masked controlled clinical trial"],"prefix":"10.1136","volume":"108","clinical-trial-number":[{"clinical-trial-number":"nct05754437","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05754437","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05754437","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-0289","authenticated-orcid":false,"given":"Giuseppe","family":"Giannaccare","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Borselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Carnovale Scalzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-5101","authenticated-orcid":false,"given":"Giovanni","family":"Scalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Pietropaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Fratto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-6941","authenticated-orcid":false,"given":"Marco","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-3942","authenticated-orcid":false,"given":"Angeli Christy","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Scorcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"2024072308350677000_108.8.1172.1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jtos.2023.04.011","article-title":"TFOS lifestyle: impact of elective medications and procedures on the ocular surface","volume":"29","author":"Gomes","year":"2023","journal-title":"Ocul Surf"},{"key":"2024072308350677000_108.8.1172.2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s40123-021-00332-7","article-title":"Iatrogenic dry eye disease: dealing with the conundrum of post-cataract discomfort. 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