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Eyes in the longitudinal cohort with a slope greater than that found in 95 percentile of separate healthy test\u2013retest series for FAZ area were categorised into FAZ progressors; all other eyes were defined as FAZ non-progressors. A generalised linear mixed-effect model was used to investigate the association of FAZ progressors with demographic and clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Faster ganglion cell complex (GCC) thinning and faster VF mean deviation (MD) loss were found in eyes with FAZ progressors compared with FAZ non-progressors (mean difference: \u22120.7 (95% CI, \u22121.4 to \u22120.1)\u2009\u00b5m\/y; p=0.026, \u22120.3 (\u22120.5 to \u22120.1)\u2009dB\/y; p=0.017, respectively), while whole image vessel density was not associated with FAZ progressors (p=0.929). SD of intraocular pressure (IOP) and IOP range were also associated with FAZ progressors in separate multivariable models (OR: 1.54 (1.02 to 2.32) per 1\u2009mm Hg higher, p=0.041; OR: 1.20 (1.01 to 1.41) per 1\u2009mm Hg higher; p=0.035, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant FAZ increase was weakly associated with moderately faster rates of both GCC thinning and VF MD loss, but not macular vessel density change in glaucoma eyes. Additional studies are needed to elucidate the pathophysiological associations between macula GCC thinning and FAZ area increases in glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-323970","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T18:25:16Z","timestamp":1703269516000},"page":"1101-1106","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Association of foveal avascular zone change and glaucoma 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