{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:52:58Z","timestamp":1765983178308,"version":"3.48.0"},"reference-count":35,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018703","name":"HORIZON EUROPE European Innovation Council","doi-asserted-by":"publisher","award":["675033"],"award-info":[{"award-number":["675033"]}],"id":[{"id":"10.13039\/100018703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,3,27]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Due to technical limitations of commonly used tonometry devices, the effects of physical exercise on intraocular pressure (IOP) have never been studied during exercise. This study continuously monitored IOP variations in patients with glaucoma during physical exercise using an implanted IOP microsensor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 10 participants (six male and four female) with open-angle glaucoma (age range: 67\u201379), previously implanted with an IOP sensor, were included. We monitored IOP telemetrically during a 10 min session on a bicycle ergometer with a stepwise power increase from 0 to 75 W, in 25\u2009W increments, at 2\u2009min intervals. We also recorded IOP during the 2\u2009min resting period after the exercise compared with resting baseline before exercise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average IOP increased from 15.4\u00b11.3\u2009mm Hg at rest to 18.0\u00b11.3\u2009mm Hg at 75 W and returned to 14.4\u00b11.0\u2009mm Hg during the resting period after exercise. During the resting period after the activity, average IOP reduced below baseline in 8 out of 10 patients (\u0394IOP=\u22120.98\u00b10.57\u2009mm Hg, p=0.12). Both systolic blood pressure and heart rate were highly correlated with IOP during the exercise (R\n                      <jats:sup>\u00b2<\/jats:sup>\n                      =0.997, p=0.002\u2009and R\n                      <jats:sup>\u00b2<\/jats:sup>\n                      =0.986, p=0.007, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In our study, IOP, heart rate and blood pressure increased and decreased with physical intensity, suggesting these parameters are closely linked and potentially driven by a common mechanism during aerobic exercise. Further studies with larger patient groups are warranted to better understand the mechanisms involved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2023-324034","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T13:20:20Z","timestamp":1746192020000},"page":"1138-1143","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the effect of physical activity on intraocular pressure using a novel implanted telemetric pressure sensor"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7591-0037","authenticated-orcid":false,"given":"Vincenzo","family":"Pennisi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-6360","authenticated-orcid":false,"given":"Jacqueline J O N","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Neustaeter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Ehmer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen","family":"Thieme","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-9638","authenticated-orcid":false,"given":"Michael B","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Choritz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Medical faculty of the Otto-von-Guericke-University, Magdeburg, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"2025121706501134000_109.10.1138.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1444-0938.2010.00564.x"},{"key":"2025121706501134000_109.10.1138.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00138-X"},{"key":"2025121706501134000_109.10.1138.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.017"},{"key":"2025121706501134000_109.10.1138.4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100020100038"},{"key":"2025121706501134000_109.10.1138.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.072546"},{"key":"2025121706501134000_109.10.1138.6","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2014.924146"},{"key":"2025121706501134000_109.10.1138.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2013.07.004"},{"key":"2025121706501134000_109.10.1138.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.10.007"},{"key":"2025121706501134000_109.10.1138.9","article-title":"Microvascular endothelial function and primary open angle glaucoma","volume":"11","author":"Mudassar Imran Bukhari","year":"2019","journal-title":"Ther Adv Ophthalmol"},{"key":"2025121706501134000_109.10.1138.10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201729","article-title":"Optic disc microvasculature dropout in primary open-angle glaucoma measured with optical coherence tomography angiography","volume":"13","author":"Akagi","year":"2018","journal-title":"PLoS One"},{"key":"2025121706501134000_109.10.1138.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.10.012"},{"key":"2025121706501134000_109.10.1138.12","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001692"},{"key":"2025121706501134000_109.10.1138.13","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31819e420f"},{"key":"2025121706501134000_109.10.1138.14","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.10.3.23","article-title":"Retina Vascular Perfusion Dynamics During Exercise With and Without Face Masks in Healthy Young Adults: An OCT Angiography Study","volume":"10","author":"Hua","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"2025121706501134000_109.10.1138.15","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13661"},{"key":"2025121706501134000_109.10.1138.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)74388-0"},{"key":"2025121706501134000_109.10.1138.17","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.200689"},{"key":"2025121706501134000_109.10.1138.18","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080080056027"},{"key":"2025121706501134000_109.10.1138.19","first-page":"1011","article-title":"Mechanism of exercise-induced ocular hypotension","volume":"40","author":"Martin","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025121706501134000_109.10.1138.20","doi-asserted-by":"publisher","DOI":"10.1080\/03014469500004202"},{"key":"2025121706501134000_109.10.1138.21","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.45.561"},{"key":"2025121706501134000_109.10.1138.22","first-page":"60","article-title":"How to measure intraocular pressure: applanation tonometry","volume":"25","author":"Stevens","year":"2012","journal-title":"Community Eye Health"},{"key":"2025121706501134000_109.10.1138.23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14925"},{"key":"2025121706501134000_109.10.1138.24","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7878"},{"key":"2025121706501134000_109.10.1138.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-021-05315-9"},{"key":"2025121706501134000_109.10.1138.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56562-0"},{"key":"2025121706501134000_109.10.1138.27","doi-asserted-by":"publisher","DOI":"10.1159\/000310596"},{"key":"2025121706501134000_109.10.1138.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01167.x"},{"key":"2025121706501134000_109.10.1138.29","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000156134.38495.0b"},{"key":"2025121706501134000_109.10.1138.30","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_585_18"},{"key":"2025121706501134000_109.10.1138.31","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/jamaophthalmol.2013.2874","article-title":"Validity of the results of a contact lens sensor?","volume":"131","author":"Faschinger","year":"2013","journal-title":"JAMA Ophthalmol"},{"key":"2025121706501134000_109.10.1138.32","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31829e5635"},{"key":"2025121706501134000_109.10.1138.33","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12051"},{"key":"2025121706501134000_109.10.1138.34","doi-asserted-by":"publisher","DOI":"10.1097\/00006324-200306000-00013"},{"key":"2025121706501134000_109.10.1138.35","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2019.1617354"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2023-324034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:50:24Z","timestamp":1765983024000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2023-324034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,9,23]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1136\/bjo-2023-324034"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2023-324034","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"type":"print","value":"0007-1161"},{"type":"electronic","value":"1468-2079"}],"subject":[],"published":{"date-parts":[[2025,5,2]]}}}