{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:26:57Z","timestamp":1787952417860,"version":"build-2784847793"},"reference-count":35,"publisher":"BMJ","issue":"11","funder":[{"name":"the National Eye Institute, National Institutes of Health","award":["K23EY028230"],"award-info":[{"award-number":["K23EY028230"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,3,3]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome\/toxic epidermal necrolysis (SJS\/TEN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study evaluated all patients diagnosed with SJS\/TEN between 2008 and 2020 within our hospital network who received AMT in the acute phase according to our protocol and had at least one ophthalmic follow-up in the chronic phase. Primary outcomes included best-corrected visual acuity (BCVA) at the most recent visit, presence of a severe ocular complication (SOC) via predefined criteria, time to procedure and duration of procedure. Random effects model analysis was used to evaluate the impact of potential covariates on outcome measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 23 patients (45 eyes) were included: 14 patients (27 eyes) in the AMT suture group and 9 patients (18 eyes) in the AMT glue group. There was no difference between the two groups in BCVA at the most recent visit (p=0.5112) or development of a SOC (p=1.000). The glue method was shorter in duration than the suture method (p&lt;0.001). Random effects model additionally indicated that there was no difference in BCVA at most recent follow-up between patients who had received glued versus sutured AMT (p=0.1460).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our glued technique for AMT is as effective as our sutured technique in stabilising the ocular surface and mitigating chronic ocular complications in SJS\/TEN. The glued technique is also shorter in duration and performed more expediently than the sutured technique.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-324076","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T17:20:52Z","timestamp":1710523252000},"page":"1508-1513","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Long-term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome\/toxic epidermal necrolysis: a comparative study"],"prefix":"10.1136","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-9079","authenticated-orcid":false,"given":"Ramy","family":"Rashad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-0536","authenticated-orcid":false,"given":"Swapna S","family":"Shanbhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panotsom","family":"Ngowyutagon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad A","family":"Tahboub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Haseeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chodosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7385-6534","authenticated-orcid":false,"given":"Hajirah N","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"2025040502501870000_108.11.1508.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.035"},{"key":"2025040502501870000_108.11.1508.2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31802eb264"},{"key":"2025040502501870000_108.11.1508.3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/ICU.0000000000000312","article-title":"Ocular manifestations of Stevens-Johnson syndrome and their management","volume":"27","author":"Saeed","year":"2016","journal-title":"Curr Opin Ophthalmol"},{"key":"2025040502501870000_108.11.1508.4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ajo.2019.07.006","article-title":"Long-term effect of a treatment protocol for acute ocular involvement in Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"208","author":"Shanbhag","year":"2019","journal-title":"Am J Ophthalmol"},{"key":"2025040502501870000_108.11.1508.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2568-8"},{"key":"2025040502501870000_108.11.1508.6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jtos.2016.02.001","article-title":"Acute and chronic ophthalmic involvement in Stevens-Johnson syndrome\/toxic epidermal necrolysis - a comprehensive review and guide to therapy","volume":"14","author":"Kohanim","year":"2016","journal-title":"Ocul Surf"},{"key":"2025040502501870000_108.11.1508.7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3109\/08820538.2015.1114841","article-title":"Chronic ocular complications of Stevens-Johnson syndrome and toxic epidermal Necrolysis: the role of systemic immunomodulatory therapy","volume":"31","author":"Chang","year":"2016","journal-title":"Semin Ophthalmol"},{"key":"2025040502501870000_108.11.1508.8","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2013.27.5.331"},{"key":"2025040502501870000_108.11.1508.9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajo.2015.05.002","article-title":"Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"160","author":"Sotozono","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"2025040502501870000_108.11.1508.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00900-9"},{"key":"2025040502501870000_108.11.1508.11","doi-asserted-by":"crossref","unstructured":"Sinha R , Tinwala S , Shekhar H , et al . 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