{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:06:57Z","timestamp":1792480017880,"version":"4.5.0"},"reference-count":28,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09717"],"award-info":[{"award-number":["21K09717"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006680","name":"Takeda Medical Research Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100006680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,12,23]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO<jats:sub>2<\/jats:sub>), and developed a risk prediction model for severe ROP using birth data and SpO<jats:sub>2<\/jats:sub>data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital in Japan. We extracted data on birth weight (BW), birth length, gestational age (GA) and minute-by-minute SpO<jats:sub>2<\/jats:sub>during the first 20 days from the medical records. We defined four SpO<jats:sub>2<\/jats:sub>variables using sequential measurements. Multivariate logistic regression was used to develop a model that combined birth data and SpO<jats:sub>2<\/jats:sub>data to predict treatment-requiring ROP (TR-ROP). The model\u2019s performance was evaluated using the area under the receiver operating characteristic curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 350 infants, 83 (23.7%) required ROP treatment. The SpO<jats:sub>2<\/jats:sub>variables in infants with TR-ROP differed significantly from those with non-TR-ROP. The average SpO<jats:sub>2<\/jats:sub>and high SpO<jats:sub>2<\/jats:sub>showed strong associations with GA (r=0.73\u2009and r=0.70, respectively). The model incorporating birth data and the four SpO<jats:sub>2<\/jats:sub>variables demonstrated good discriminative ability (AUC=0.83), but it did not outperform the model incorporating BW and GA (AUC=0.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Data obtained by continuous SpO<jats:sub>2<\/jats:sub>monitoring demonstrated valuable associations with severe ROP, as well as with GA. Differences in the distribution of average SpO<jats:sub>2<\/jats:sub>and high SpO<jats:sub>2<\/jats:sub>between infants with TR-ROP and non-TR-ROP could be used to establish efficient cut-off values for risk determination.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2023-324225","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T18:20:16Z","timestamp":1709749216000},"page":"1275-1280","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort"],"prefix":"10.1136","volume":"108","author":[{"given":"Hiroshi","family":"Kubota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7909-7332","authenticated-orcid":false,"given":"Yoko","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7492-6303","authenticated-orcid":false,"given":"Ryo","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Hatsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Ineyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3148-9892","authenticated-orcid":false,"given":"Katsuya","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohji","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"issue":"Suppl 1","key":"2024082203451038000_108.9.1275.1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/pr.2013.205","article-title":"Preterm-associated visual impairment and estimates of retinopathy of Prematurity at regional and global levels for 2010","volume":"74 Suppl 1","author":"Blencowe","year":"2013","journal-title":"Pediatr Res"},{"key":"2024082203451038000_108.9.1275.2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-310041"},{"key":"2024082203451038000_108.9.1275.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"2024082203451038000_108.9.1275.4","doi-asserted-by":"crossref","first-page":"101018","DOI":"10.1016\/j.preteyeres.2021.101018","article-title":"Assessment and management of retinopathy of Prematurity in the era of anti-vascular endothelial growth factor (VEGF)","volume":"88","author":"Tsai","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"2024082203451038000_108.9.1275.5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000490372","article-title":"Variations in oxygen saturation targeting, and retinopathy of Prematurity screening and treatment criteria in neonatal intensive care units: an international survey","volume":"114","author":"Darlow","year":"2018","journal-title":"Neonatology"},{"key":"2024082203451038000_108.9.1275.6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5694\/j.1326-5377.1951.tb109040.x","article-title":"Intensive oxygen therapy as a possible cause of Retrolental Fibroplasia; 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