{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:35:02Z","timestamp":1787016902702,"version":"build-2736575974"},"reference-count":30,"publisher":"BMJ","issue":"9","funder":[{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["18-ST2-005"],"award-info":[{"award-number":["18-ST2-005"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["CS-2018"],"award-info":[{"award-number":["CS-2018"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2023,11,12]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/aims<\/jats:title>\n                    <jats:p>The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6.6 events per 1\u2009000\u2009000 vaccinated individuals. Anterior uveitis was the most common phenotype (58.3%), followed by optic neuritis in 39.3%. Median number of days between vaccination and onset was 8\u2009days. Resolution of the event was seen in 52.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ocular inflammatory events following COVID-19 vaccination have a very rare prevalence in the UK. There is no increase in the reporting rate of uveitis, optic neuritis and scleritis following COVID-19 vaccination when compared with the range of incidence in the UK population. The Yellow Card System represents a vital instrument within the domain of pharmacovigilance, empowering patients and healthcare professionals to contribute to the ongoing monitoring of medication safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2023-324503","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T13:21:20Z","timestamp":1701091280000},"page":"1200-1203","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK"],"prefix":"10.1136","volume":"108","author":[{"given":"Ilaria","family":"Testi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Soomro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pavesio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8933-5864","authenticated-orcid":false,"given":"Ameenat Lola","family":"Solebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"2024082203451032000_108.9.1200.1","doi-asserted-by":"crossref","DOI":"10.1186\/s40942-019-0180-0","article-title":"Diffuse uveitis and chorioretinal changes after yellow fever vaccination: a re- emerging epidemic","volume":"5","author":"Marinho","year":"2019","journal-title":"Int J Retina Vitreous"},{"key":"2024082203451032000_108.9.1200.2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/09273948.2019.1626188","article-title":"Vaccine- associated uveitis","volume":"27","author":"Cunningham","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"2024082203451032000_108.9.1200.3","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/09273948.2020.1734213","article-title":"Presumed unilateral acute idiopathic maculopathy following H1N1 vaccination","volume":"29","author":"Jorge","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"2024082203451032000_108.9.1200.4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajoc.2020.100845","article-title":"Multiple evanescent white DOT syndrome following influenza immunization - 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