{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T12:52:18Z","timestamp":1787057538554,"version":"build-2736575974"},"reference-count":35,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,2,29]]},"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The purpose of this study was to assess the prevalence of strabismus and nystagmus and to analyse associated factors in preterm and full-term infants in adulthood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Gutenberg Prematurity Eye Study is a retrospective cohort study with a prospective ophthalmological examination of participants born preterm and full-term (aged 18\u201352 years). Perinatal data were carefully assessed for risk factors and comprehensive ophthalmological examinations were conducted. The association between strabismus and nystagmus was assessed by analysing 16 different perinatal and actual risk factors in multivariable analysis. Participants were grouped into full-term controls (gestational age (GA) at birth \u226537 weeks), preterm participants without retinopathy of prematurity (ROP) and GA 33\u201336 weeks (group 2), GA 29\u201332 weeks (group 3), GA \u226428 weeks (group 4), non-treated ROP (group 5) and treated ROP (group 6).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 892 eyes of 450 preterm and full-term individuals (mean age: 28.6 years, SD: \u00b1 8.6 years, 251 females) were included. Strabismus was observed in 2.1% (3\/140), 6.6% (9\/137), 17.4% (16\/92), 11.1% (2\/18), 27.1% (13\/48) and 60% (9\/15) of participants and nystagmus in 0.7% (1\/140), 1.5% (2\/137), 4.3% (4\/92), 5.6% (1\/18), 10.4% (5\/48) and 26.7% (4\/15) of participants in the respective groups. In the multivariable regression model, strabismus was associated with GA (OR=0.90; p=0.046), anisometropia \u22651.5 diopter (OR=3.87; p=0.003), hypermetropia \u22652 diopter (OR=9.89; p&lt;0.001) and astigmatism \u22651.5 diopter (OR=2.73; p=0.017). Esotropia was more frequent than exotropia and hypermetropia\/hypometropia. Most strabismus cases occurred within the first 10 years of life. The strongest predictor associated with nystagmus was perinatal adverse events (OR=15.8; p=0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low GA and refraction of the eye are independent risk factors for strabismus, which typically occurs in the first 10 years of life. Perinatal adverse events are the most important factors for the presence of nystagmus in adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2023-324698","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T13:23:03Z","timestamp":1710854583000},"page":"1590-1597","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of strabismus and risk factors in adults born preterm with and without retinopathy of prematurity: results from the Gutenberg Prematurity Eye 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