{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:28:56Z","timestamp":1754144936410,"version":"3.41.2"},"reference-count":20,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,9,3]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate nyctohemeral effects of topical beta-adrenoceptor blocking agents and their fixed combinations on intraocular pressure (IOP) in patients with primary open-angle glaucoma implanted with an ocular telemetry sensor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>22 patients who had previously been implanted with a sulcus-based IOP sensor (eyemate) were included in this prospective clinical trial. Three classes of medications were analysed: beta-blockers (BB), fixed combination of BB and carbonic anhydrase inhibitors (BB-CAI), and combinations of BB and prostaglandin analogues (BB-PGAs). SD and IQR of IOP were calculated and used as surrogates of nyctohemeral IOP variation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean (\u00b1SD) age of patients was 67.8\u00b16.8 years (36.4% female). A total of 50\u2009920 IOP measurements over 4084 days from 10 eyes were included. The mean 24-hour IOP (\u00b1SE) with BB-PGA (17.3\u00b11.1\u2009mm Hg) was significantly (p&lt;0.001) less than that with BB (18.8\u00b11.1\u2009mm Hg). Mean 24-hour IOP with BB-CAI (18.4\u00b11.1\u2009mm Hg) was similar (p&gt;0.05) to that with the other two medications. Mean 24-hour SD of IOP with BB-PGA (1.9\u00b10 .2\u2009mm Hg) and BB-CAI (2.0\u00b10.2\u2009mm Hg) were significantly (p&lt;0.05) less than that with BB (2.4\u00b10.2\u2009mm Hg). Mean 24-hour IQR of IOP with BB-PGA (2.3\u00b10.4\u2009mm Hg) was significantly less than that with both BB (3.8\u00b10.4\u2009mm Hg) and BB-CAI (3.2\u00b10.4\u2009mm Hg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Continual IOP monitoring shows that combinations of BB-PGAs have more pronounced effects on lowering 24-hour IOP fluctuations than BB-CAIs and BBs alone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03651336\">NCT03651336<\/jats:ext-link>.<\/jats:p>\n               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