{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:28:59Z","timestamp":1754144939792,"version":"3.41.2"},"reference-count":35,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100000367","name":"British Council for Prevention of Blindness","doi-asserted-by":"publisher","award":["165223"],"award-info":[{"award-number":["165223"]}],"id":[{"id":"10.13039\/501100000367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870655"],"award-info":[{"award-number":["81870655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017645","name":"Moorfields Eye Charity","doi-asserted-by":"crossref","award":["166186"],"award-info":[{"award-number":["166186"]}],"id":[{"id":"10.13039\/501100017645","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,11,3]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To compare the baseline clinical characteristics and patterns of visual field defects between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) in the Laser in Glaucoma and Ocular Hypertension (LiGHT) China subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients (n=622) were recruited at Zhongshan Ophthalmic Center from 2015 to 2019. 1105 open-angle glaucoma eyes of 622 patients were classified as NTG (n=559) and HTG eyes (n=546) according to the baseline intraocular pressure (IOP) of 21\u2009mm Hg. The mean deviation (MD), regional MD of the Glaucoma Hemifield Test regions and regional difference values were calculated. Daytime phasing IOP was recorded at 8:00, 10:00, 11:30, 14:30 and 17:00 hour. Multiple regression analyses were conducted for each regional difference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with NTG were older, more likely to be female, hypertensive and suffer ischaemic heart disease than patients with HTG (p&lt;0.05 for all comparisons). HTG showed higher mean daytime phasing IOP and higher daytime fluctuations than NTG (p&lt;0.001 for all comparisons). HTG and NTG showed similar MD overall (p=0.665). NTG showed significantly greater hemifield asymmetry than HTG. The two arcuate regional differences in NTG were significantly associated with daytime IOP fluctuations (p&lt;0.01 in both regions).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In the LiGHT China trial, NTG and HTG showed similar visual field defects severity at enrolment. However, NTG showed more severe hemifield asymmetry compared with HTG, and higher short-time IOP fluctuations might exacerbate this asymmetry in NTG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2023-324852","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T13:35:17Z","timestamp":1732023317000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of baseline clinical characteristics and patterns of visual field defects between high-tension and normal-tension glaucoma"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-4804","authenticated-orcid":false,"given":"Zidong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-9652","authenticated-orcid":false,"given":"Yangfan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-377X","authenticated-orcid":false,"given":"Yuning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongxuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Nathwani","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gus","family":"Gazzard","sequence":"additional","affiliation":[{"name":"National Institute for Health and Care Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and University College London Institute of Ophthalmology, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-7164","authenticated-orcid":false,"given":"Minbin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Glaucoma, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"},{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2025071523150788000_109.5.587.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.016"},{"key":"2025071523150788000_109.5.587.2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7472"},{"key":"2025071523150788000_109.5.587.3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1759"},{"key":"2025071523150788000_109.5.587.4","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0615"},{"key":"2025071523150788000_109.5.587.5","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305962"},{"key":"2025071523150788000_109.5.587.6","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.3.4"},{"key":"2025071523150788000_109.5.587.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.07.033"},{"key":"2025071523150788000_109.5.587.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.08.027"},{"key":"2025071523150788000_109.5.587.9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13742"},{"key":"2025071523150788000_109.5.587.10","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.344831"},{"key":"2025071523150788000_109.5.587.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.08.051"},{"key":"2025071523150788000_109.5.587.12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11792"},{"key":"2025071523150788000_109.5.587.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.10.031"},{"key":"2025071523150788000_109.5.587.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.047"},{"key":"2025071523150788000_109.5.587.15","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.8.1010"},{"key":"2025071523150788000_109.5.587.16","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001872"},{"key":"2025071523150788000_109.5.587.17","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000667"},{"key":"2025071523150788000_109.5.587.18","doi-asserted-by":"crossref","unstructured":"Jiang J , Ye C , Zhang C , et al . Intraocular asymmetry of visual field defects in primary angle-closure glaucoma, high-tension glaucoma, and normal-tension glaucoma in a Chinese population. Sci Rep 2021;11. doi:10.1038\/s41598-021-91173-8","DOI":"10.1038\/s41598-021-91173-8"},{"key":"2025071523150788000_109.5.587.19","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/327326","article-title":"Visual field loss morphology in high- and normal-tension glaucoma","volume":"2012","author":"Iester","year":"2012","journal-title":"J Ophthalmol"},{"key":"2025071523150788000_109.5.587.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.04.020"},{"key":"2025071523150788000_109.5.587.21","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-320128"},{"key":"2025071523150788000_109.5.587.22","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310870"},{"key":"2025071523150788000_109.5.587.23","unstructured":"Hodapp EA , Parrish RK , Anderson DR . Clinical Decisions in Glaucoma. 1993."},{"key":"2025071523150788000_109.5.587.24","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080180084033"},{"key":"2025071523150788000_109.5.587.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-0845-9"},{"key":"2025071523150788000_109.5.587.26","first-page":"2461","article-title":"Appropriate statistical methods to account for similarities in binary outcomes between fellow eyes","volume":"35","author":"Katz","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2025071523150788000_109.5.587.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.03.005"},{"key":"2025071523150788000_109.5.587.28","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.128819"},{"key":"2025071523150788000_109.5.587.29","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0042-2"},{"key":"2025071523150788000_109.5.587.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)00964-3"},{"key":"2025071523150788000_109.5.587.31","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200004000-00002"},{"key":"2025071523150788000_109.5.587.32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702351"},{"key":"2025071523150788000_109.5.587.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.029"},{"key":"2025071523150788000_109.5.587.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.07.060"},{"key":"2025071523150788000_109.5.587.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.08.031"}],"container-title":["British Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bjo-2023-324852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T06:16:12Z","timestamp":1752646572000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjo.bmj.com\/lookup\/doi\/10.1136\/bjo-2023-324852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,4,22]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1136\/bjo-2023-324852"],"URL":"https:\/\/doi.org\/10.1136\/bjo-2023-324852","relation":{},"ISSN":["0007-1161","1468-2079"],"issn-type":[{"type":"print","value":"0007-1161"},{"type":"electronic","value":"1468-2079"}],"subject":[],"published":{"date-parts":[[2024,11,19]]}}}