{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:26:14Z","timestamp":1783441574390,"version":"3.54.6"},"reference-count":31,"publisher":"BMJ","issue":"12","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070943"],"award-info":[{"award-number":["82070943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271068"],"award-info":[{"award-number":["82271068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Innovation Action Plan","award":["20Y11911000"],"award-info":[{"award-number":["20Y11911000"]}]},{"name":"Scientific Innovation Action Plan","award":["22Y11910400"],"award-info":[{"award-number":["22Y11910400"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,3,26]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study was to analyse the effective lens position (ELP) in patients with Marfan syndrome (MFS) and ectopia lentis (EL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with MFS undergoing lens removal and primary intraocular lens (IOL) implantation were enrolled in the study. The back-calculated ELP was obtained with the vergence formula and compared with the theoretical ELPs. The back-calculated ELP and ELP error were evaluated among demographic and biometric parameters, including axial length (AL), corneal curvature radius (CCR) and white-to-white (WTW).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 292 eyes from 200 patients were included. The back-calculated ELP was lower in patients undergoing scleral-fixated IOL than those receiving in-the-bag IOL implantation (4.54 (IQR 3.65\u20135.20) mm vs 4.98 (IQR 4.56\u20135.67) mm, p&lt;0.001). The theoretical ELP of the SRK\/T formula exhibited the highest accuracy, with no difference from the back-calculated ELP in patients undergoing in-the-bag IOL implantation (5.11 (IQR 4.83\u20135.65) mm vs 4.98 (IQR 4.56\u20135.67) mm, p=0.209). The ELP errors demonstrated significant correlations with refraction prediction error (PE): a 1\u2009mm ELP error led to PE of 2.42D (AL&lt;22\u2009mm), 1.47D (22\u2009mm\u2264AL&lt;26\u2009mm) and 0.54D (AL\u226526\u2009mm). Multivariate analysis revealed significant correlations of ELP with AL (b=0.43, p&lt;0.001), CCR (b=\u22120.85, p&lt;0.001) and WTW (b=0.41, p=0.004).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study provides novel insights into the origin of PE in patients with MFS and EL and potentially refines existing formulas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2023-325017","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T01:50:28Z","timestamp":1712800228000},"page":"1634-1641","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Influencing factors of effective lens position in patients with Marfan syndrome and ectopia lentis"],"prefix":"10.1136","volume":"108","author":[{"given":"Xin","family":"Shen","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexu","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WanNan","family":"Jia","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalei","family":"Wang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhui","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9770-5733","authenticated-orcid":false,"given":"Yongxiang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"2025071603351111000_108.12.1634.1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24383"},{"key":"2025071603351111000_108.12.1634.2","doi-asserted-by":"crossref","unstructured":"Chen T , Deng M , Zhang M , et al . 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