{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:08:20Z","timestamp":1781032100489,"version":"3.54.1"},"reference-count":29,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2024,4,29]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate efficacy and safety outcomes of the Xen 45 gel stent implant over 24 months of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis of prospectively collected data from the Fight Glaucoma Blindness observational registry. Complete success (CS) was defined as intraocular pressure (IOP) reduction \u226520% from preoperative and an IOP \u226418\u2009mm Hg and \u22656\u2009mm Hg with no secondary procedure at 2 years and without IOP-lowering medications. Qualified success (QS) was defined similarly, allowing the use of IOP-lowering medications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The Xen 45 gel stent implant was implanted in 646 eyes of 515 patients. Preoperative IOP was 21.4\u00b17.6 (mean\u00b1SD) mm Hg on 2.7\u00b11.3 IOP-lowering medication and mean deviation was \u221210.2\u00b18.4\u2009dB. After 24-month follow-up, IOP was 16.8\u00b17.3\u2009mm Hg (mean reduction of 21.7%) on 1.2\u00b11.4 IOP-lowering medications. CS and QS rates at 24 months were 26% and 48%, respectively. CS and QS were higher in the Xen stand-alone group (33% and 52%, respectively) than in the Xen+cataract group (16% and 42%, respectively). Bleb needling was performed in 28.4% of cases, and 18% underwent a secondary procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The Xen 45 gel stent implant offers acceptable long-term efficacy for the treatment of open-angle glaucoma. However, there is a significant rate of reoperation and needling, and outcomes are less effective if combined with cataract surgery.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2023-325077","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:21:09Z","timestamp":1716556869000},"page":"1672-1678","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Two-year outcomes of Xen 45 gel stent implantation in patients with open-angle glaucoma: real-world data from the Fight Glaucoma Blindness registry"],"prefix":"10.1136","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-8818","authenticated-orcid":false,"given":"Louis","family":"Arnould","sequence":"first","affiliation":[{"name":"Ophthalmology, Centre Hospitalier Universitaire de Dijon, Dijon, France"},{"name":"Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases (PEC2), (EA 7460), Dijon, 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