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All SNPs were genotyped in a Hong Kong Chinese cohort of 533 myopia subjects (including 175 high myopia, 189 moderate myopia and 189 mild myopia) and 280 non-myopic controls. The association of individual SNPs were evaluated in overall myopia and different subgroups of myopia using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A tagging SNP, rs11200647, was significantly associated with myopia (p=2.17\u00d710<jats:sup>-4<\/jats:sup>, OR=0.67). Nominal associations were detected for the AMD-associated SNP rs11200638 (p=0.0042, OR=1.37) and tagging SNPs rs12266322 (p=0.0048, OR=0.59) and rs17103569 (p=0.047, OR=1.34). The association of rs11200647 with myopia remained significant after adjusting for rs11200638, rs12266322 and rs17103569. In sub-group analysis, two tagging SNPs, rs11200647 (p=2.24\u00d710<jats:sup>-4<\/jats:sup>, OR=0.58) and rs12266322 (p=8.31\u00d710<jats:sup>-4<\/jats:sup>, OR=0.39), showed significant association with moderate myopia. In haplotype association analysis, haplotypes AT (p=1.00\u00d710<jats:sup>-4<\/jats:sup>, OR=1.77) and haplotype GT (p=0.0019, OR=0.64), defined by rs11200647 and rs66884382, were significantly associated with myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provided new evidence to support<jats:italic>HTRA1<\/jats:italic>as an associated gene for myopia, especially moderate myopia. The findings suggested that myopia and AMD may have shared genetic components.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjo-2024-325935","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T17:20:38Z","timestamp":1729012838000},"page":"456-462","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association of polymorphisms in the<i>HTRA1<\/i>gene with myopia"],"prefix":"10.1136","volume":"109","author":[{"given":"Shu Ying","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Mei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pancy O S","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi 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