{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:36:20Z","timestamp":1790048180240,"version":"4.0.1"},"reference-count":34,"publisher":"BMJ","issue":"8","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171075"],"award-info":[{"award-number":["82171075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515120028"],"award-info":[{"award-number":["2023B1515120028"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202308440506"],"award-info":[{"award-number":["202308440506"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the launch fund of Guangdong Provincial People\u2019s Hospital for NSFC","award":["8217040546"],"award-info":[{"award-number":["8217040546"]}]},{"name":"Science and Technology Program of Guangzhou","award":["20220610092"],"award-info":[{"award-number":["20220610092"]}]},{"name":"Brolucizumab Efficacy and Safety Single-Arm Descriptive Trial in Patients with Persistent Diabetic Macular Edema","award":["2024-29"],"award-info":[{"award-number":["2024-29"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,1,9]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To investigate the associations between a healthy lifestyle score and retinal neurovascular health, and explore whether lower inflammation levels mediate these associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study is based on the UK Biobank. The healthy lifestyle score ranged from 0 to 6 and comprised physical activity, diet, sleep duration, smoking status, alcohol consumption and bodyweight. Outcomes included retinal diseases (age-related macular degeneration (AMD) and retinal vascular occlusion (RVO)) from hospital admission records (378\u2009648 participants), retinal vascular metrics from retinal photography (32\u2009226 participants) and retinal neural metrics from optical coherence tomography (42\u2009557 participants). An INFLA-score was used to characterise inflammation levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants with better healthy life score (scored from 5 to 6) were associated with a 29% lower risk of AMD, 25% lower risk of RVO, 2% increase in artery-to-vein ratio (AVR), 0.22\u2009\u00b5m increase in central retinal artery equivalent, 0.36\u2009\u00b5m decrease in central retinal vein equivalent (CRVE), 0.004 increase in fractal dimension, 0.38\u2009\u00b5m increase in retinal nerve fibre layer, 0.69\u2009\u00b5m increase in ganglion cell-inner plexiform layer (GCIPL) and 0.35\u2009\u00b5m increase in photoreceptor segment (PS) compared with those with worst lifestyle score (scored from 0 to 1) (all p<jats:sub>trend<\/jats:sub>&lt;0.01). In addition, INFLA-score partially mediated the associations between healthy lifestyle score and increased risk of AMD (mediated proportion (MP): 14.8%), higher AVR (MP: 12.76%), narrower CRVE (MP: 24.49%), thicker GCIPL (MP: 4.97%) and thicker PS (MP: 26.86%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Great adherence to a healthier lifestyle was associated with better retinal health in a dose-response manner. Lower inflammation partially mediated the association between a healthy lifestyle score and retinal health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bjo-2024-326184","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T13:20:25Z","timestamp":1739193625000},"page":"858-867","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between a healthy lifestyle score and retinal neurovascular health"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7718-5750","authenticated-orcid":false,"given":"Xiaomin","family":"Zeng","sequence":"first","affiliation":[{"name":"Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, 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