{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:12:47Z","timestamp":1782835967024,"version":"3.54.5"},"reference-count":30,"publisher":"BMJ","issue":"10","funder":[{"name":"Peking Union Medical College Hospital Research Funding for Postdoc, China","award":["2024-PUMCH-kyfyjj202413"],"award-info":[{"award-number":["2024-PUMCH-kyfyjj202413"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2021B0101420005"],"award-info":[{"award-number":["2021B0101420005"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2404304"],"award-info":[{"award-number":["2022YFC2404304"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Level Hospital Clinical Research Funding, China","award":["2022-PUMCH-B-101"],"award-info":[{"award-number":["2022-PUMCH-B-101"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Ophthalmol"],"accepted":{"date-parts":[[2025,4,24]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pathological myopia (PM) has emerged as a leading cause of global visual impairment, early detection and precise grading of PM are crucial for timely intervention. The atrophy, traction and neovascularisation (ATN) system is applied to define PM progression and stages with precision. This study focuses on constructing a comprehensive PM image dataset comprising both fundus and optical coherence tomography (OCT) images and developing a bimodal artificial intelligence (AI) classification model for ATN grading in PM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-centre retrospective cross-sectional study collected 2760 colour fundus photographs and matching OCT images of PM from January 2019 to November 2022 at Peking Union Medical College Hospital. Ophthalmology specialists labelled and inspected all paired images using the ATN grading system. The AI model used a ResNet-50 backbone and a multimodal multi-instance learning module to enhance interaction across instances from both modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Performance comparisons among single-modality fundus, OCT and bimodal AI models were conducted for ATN grading in PM. The bimodality model, dual-deep learning (DL), demonstrated superior accuracy in both detailed multiclassification and biclassification of PM, which aligns well with our observation from instance attention-weight activation maps. The area under the curve for severe PM using dual-DL was 0.9635 (95% CI 0.9380 to 0.9890), compared with 0.9359 (95% CI 0.9027 to 0.9691) for the solely OCT model and 0.9268 (95% CI 0.8915 to 0.9621) for the fundus model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our novel bimodal AI multiclassification model for PM ATN staging proves accurate and beneficial for public health screening and prompt referral of PM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjo-2024-326252","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T16:24:03Z","timestamp":1747844643000},"page":"1179-1186","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Enhancing pathological myopia diagnosis: a bimodal artificial intelligence approach integrating fundus and optical coherence tomography imaging for precise atrophy, traction and neovascularisation grading"],"prefix":"10.1136","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-8198","authenticated-orcid":false,"given":"Zhiyan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Yang","sequence":"additional","affiliation":[{"name":"Visionary Intelligence Ltd, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-5877","authenticated-orcid":false,"given":"Huan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China"},{"name":"Key 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